妊娠期哮喘对不同性别婴儿肠道菌群影响差异
2017/12/29
摘要
妊娠期间的哮喘会导致婴儿生长发育迟缓，这一影响有性别差异性。乳酸菌等微生物可影响婴儿生长。本研究为了探讨在妊娠期哮喘母亲产下的婴儿肠道乳酸菌和其他微生物是否减少，以及这种变化是否与婴儿的性别有关。
本研究选取了来自加拿大健康婴儿纵向发展（CHILD）研究中的母婴配对（N=1021），利用基因测序的方法，比较了在怀孕过程中母亲治疗和未治疗哮喘，对3到4个月婴儿粪便菌群数量影响差异进行分析。婴儿性别、母亲种族、孕前超重、特异反应性状态、生育模式、母乳喂养状态、分娩期抗生素治疗等都作为变量分析。
与出生模式和其他协变量相独立，母亲在产前诊断为哮喘的，其男性白种人的婴儿肠道乳酸菌含量较低。如果哮喘的母亲有产前超重，其男性婴儿肠道中的乳酸菌会更低，而女性婴儿肠道中富含类杆菌。与之类似，根据母亲产前哮喘状态，对食物或环境过敏的女性所产婴儿肠道微生物更多见。
男婴的肠道乳酸菌更少，但有妊娠期哮喘的母亲，其产下的3-4月龄的女婴肠道类杆菌较多。
Sex-specific impact of asthma during pregnancy on infant gut microbiota
Petya T. Koleva, Hein M. Tun, Theodore Konya, David S. Guttman, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Malcolm R. Sears, James A. Scott, Anita L. Kozyrskyj
European Respiratory Journal 2017 50: 1700280; DOI: 10.1183/13993003.00280-2017
Abstract
Asthma during pregnancy is associated with retardation of fetal growth in a sex-specific manner. Lactobacilli microbes influence infant growth. This study aimed to determine whether lactobacilli and other microbes are reduced in the gut of infants born to an asthmatic mother, and whether this differs by the sex of the infant.
Mother-infant pairs (N=1021) from the Canadian Healthy Infant Longitudinal Development full-term cohort were studied. The abundance of infant faecal microbiota at 3–4 months, profiled by gene sequencing, was compared between both women with and without asthma treatment during pregnancy. Infant sex, maternal ethnicity, pre-pregnancy overweight and atopy status, birth mode, breastfeeding status and intrapartum antibiotic treatment were tested as covariates.
Independent of birth mode and other covariates, male, Caucasian infants born to women with prenatal asthma harboured fewer lactobacilli in the gut at 3–4 months of age. If asthmatic mothers had pre-pregnancy overweight, the abundance of Lactobacillus in males was further reduced in the infant gut, whereas the microbiota of female infants was enriched with Bacteroidaceae. Similar differences in infant gut microbial composition according to maternal prenatal asthma status were also more evident among women with food or environmental allergies.
Gut lactobacilli were less abundant in male infants, but Bacteroidaceae were more abundant in female infants at 3–4 months of age, following maternal asthma during pregnancy.
妊娠期间的哮喘会导致婴儿生长发育迟缓，这一影响有性别差异性。乳酸菌等微生物可影响婴儿生长。本研究为了探讨在妊娠期哮喘母亲产下的婴儿肠道乳酸菌和其他微生物是否减少，以及这种变化是否与婴儿的性别有关。
本研究选取了来自加拿大健康婴儿纵向发展（CHILD）研究中的母婴配对（N=1021），利用基因测序的方法，比较了在怀孕过程中母亲治疗和未治疗哮喘，对3到4个月婴儿粪便菌群数量影响差异进行分析。婴儿性别、母亲种族、孕前超重、特异反应性状态、生育模式、母乳喂养状态、分娩期抗生素治疗等都作为变量分析。
与出生模式和其他协变量相独立，母亲在产前诊断为哮喘的，其男性白种人的婴儿肠道乳酸菌含量较低。如果哮喘的母亲有产前超重，其男性婴儿肠道中的乳酸菌会更低，而女性婴儿肠道中富含类杆菌。与之类似，根据母亲产前哮喘状态，对食物或环境过敏的女性所产婴儿肠道微生物更多见。
男婴的肠道乳酸菌更少，但有妊娠期哮喘的母亲，其产下的3-4月龄的女婴肠道类杆菌较多。
(复旦大学附属中山医院 呼吸科 包晨 摘译 杨 冬 审校)
(European Respiratory Journal 2017 50: 1700280; DOI: 10.1183/13993003.00280-2017)
(European Respiratory Journal 2017 50: 1700280; DOI: 10.1183/13993003.00280-2017)
Sex-specific impact of asthma during pregnancy on infant gut microbiota
Petya T. Koleva, Hein M. Tun, Theodore Konya, David S. Guttman, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Malcolm R. Sears, James A. Scott, Anita L. Kozyrskyj
European Respiratory Journal 2017 50: 1700280; DOI: 10.1183/13993003.00280-2017
Abstract
Asthma during pregnancy is associated with retardation of fetal growth in a sex-specific manner. Lactobacilli microbes influence infant growth. This study aimed to determine whether lactobacilli and other microbes are reduced in the gut of infants born to an asthmatic mother, and whether this differs by the sex of the infant.
Mother-infant pairs (N=1021) from the Canadian Healthy Infant Longitudinal Development full-term cohort were studied. The abundance of infant faecal microbiota at 3–4 months, profiled by gene sequencing, was compared between both women with and without asthma treatment during pregnancy. Infant sex, maternal ethnicity, pre-pregnancy overweight and atopy status, birth mode, breastfeeding status and intrapartum antibiotic treatment were tested as covariates.
Independent of birth mode and other covariates, male, Caucasian infants born to women with prenatal asthma harboured fewer lactobacilli in the gut at 3–4 months of age. If asthmatic mothers had pre-pregnancy overweight, the abundance of Lactobacillus in males was further reduced in the infant gut, whereas the microbiota of female infants was enriched with Bacteroidaceae. Similar differences in infant gut microbial composition according to maternal prenatal asthma status were also more evident among women with food or environmental allergies.
Gut lactobacilli were less abundant in male infants, but Bacteroidaceae were more abundant in female infants at 3–4 months of age, following maternal asthma during pregnancy.
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气道直径变化是决定呼出气一氧化氮（FENO）反应哮喘控制状态的重要因素
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寡细胞型稳定期哮喘患者的临床、功能及气道炎症特点：不同痰表型的比较
