哮喘样症状随年龄增长的流行情况
2017/12/29
摘要
背景：老年人群中哮喘样症状的患病率可能受到吸烟、哮喘治疗和特应性反应的影响。
方法：欧洲共同体呼吸病健康调查组抽取20至44岁成人（13个欧洲国家的29个中心及澳大利亚）为代表性样本（N = 7844），收集其在基线、10年后、20年后哮喘样症状信息。症状发生率的净变化使用广义估计方程（经逆概率加权校正）得出，然后对中心水平估计进行meta分析。
结果：20年后喘息和非感冒诱发喘息的发生率下降（-2.4%，95% CI：-3.5%， -1.3%；−1.5%，95% CI： -2.4%状， -0.6%），但哮喘急性发作、使用哮喘药物和枯草热/鼻过敏却增加(0.6%, 95% CI： 0.1 -1.11; 3.6%, 95% CI： 3.0 - 4.2; 2.7%, 95% CI： 1.7 - 3.7)。除了枯草热/鼻过敏（仅在前10年增加），前10年的其余变化与第二个10年类似。这些喘息相关症状的减少主要见于戒烟的人群，并在那些基线报告患枯草热/鼻过敏的人群中见到。
结论：出生于1946和1970之间的欧洲人在过去的20年中喘息发生率降低，虽然他们更可能报告哮喘发作，使用哮喘药物和枯草热。喘息减少主要归因于戒烟，而不是哮喘治疗的改善。它也可能受到随着年龄增长特应性反应减少的影响。
Prevalence of asthma-like symptoms with ageing
Jarvis D, Newson R, Janson C, Corsico A, Heinrich J, Anto JM, Abramson MJ, Kirsten AM, Zock JP, Bono R, Demoly P, Leynaert B, Raherison C, Pin I, Gislason T, Jogi R, Schlunssen V, Svanes C, Watkins J, Weyler J, Pereira-Vega A, Urrutia I, Gullón JA, Forsberg B, Probst-Hensch N, Boezen HM, Martinez-Moratalla Rovira J, Accordini S, de Marco R, Burney P. Thorax. 2017 Oct 3. pii: thoraxjnl-2016-209596.
Abstract
BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy.
METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20mptoms from representative samples of adultses and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates.
RESULTS: Over 20 years the prevalence of ‘wheeze0 yea ‘wheeze in the absence of a cold lysis of centre labilityo Corsico,5 Joachim Heinrich,6Josep M Anto,7,8,9,10 Michael J Abramson,11 Anne-Marie Kir of asthma medication and hay fever/nasal allergies increased (0.6%, 95% CI 0.1 to1.11; 3.6%, 95% CI 3.0to 4.2; 2.7%, 95% CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hayfever/nasal allergies at baseline.
CONCLUSIONS: The European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.
背景：老年人群中哮喘样症状的患病率可能受到吸烟、哮喘治疗和特应性反应的影响。
方法：欧洲共同体呼吸病健康调查组抽取20至44岁成人（13个欧洲国家的29个中心及澳大利亚）为代表性样本（N = 7844），收集其在基线、10年后、20年后哮喘样症状信息。症状发生率的净变化使用广义估计方程（经逆概率加权校正）得出，然后对中心水平估计进行meta分析。
结果：20年后喘息和非感冒诱发喘息的发生率下降（-2.4%，95% CI：-3.5%， -1.3%；−1.5%，95% CI： -2.4%状， -0.6%），但哮喘急性发作、使用哮喘药物和枯草热/鼻过敏却增加(0.6%, 95% CI： 0.1 -1.11; 3.6%, 95% CI： 3.0 - 4.2; 2.7%, 95% CI： 1.7 - 3.7)。除了枯草热/鼻过敏（仅在前10年增加），前10年的其余变化与第二个10年类似。这些喘息相关症状的减少主要见于戒烟的人群，并在那些基线报告患枯草热/鼻过敏的人群中见到。
结论：出生于1946和1970之间的欧洲人在过去的20年中喘息发生率降低，虽然他们更可能报告哮喘发作，使用哮喘药物和枯草热。喘息减少主要归因于戒烟，而不是哮喘治疗的改善。它也可能受到随着年龄增长特应性反应减少的影响。
(冯敏1 张红萍1 王刚 四川大学华西医院中西医结合科呼吸病组 610041 摘译)
（2017 Oct 3. pii: thoraxjnl-2016-209596.）
（2017 Oct 3. pii: thoraxjnl-2016-209596.）
Prevalence of asthma-like symptoms with ageing
Jarvis D, Newson R, Janson C, Corsico A, Heinrich J, Anto JM, Abramson MJ, Kirsten AM, Zock JP, Bono R, Demoly P, Leynaert B, Raherison C, Pin I, Gislason T, Jogi R, Schlunssen V, Svanes C, Watkins J, Weyler J, Pereira-Vega A, Urrutia I, Gullón JA, Forsberg B, Probst-Hensch N, Boezen HM, Martinez-Moratalla Rovira J, Accordini S, de Marco R, Burney P. Thorax. 2017 Oct 3. pii: thoraxjnl-2016-209596.
Abstract
BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy.
METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20mptoms from representative samples of adultses and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates.
RESULTS: Over 20 years the prevalence of ‘wheeze0 yea ‘wheeze in the absence of a cold lysis of centre labilityo Corsico,5 Joachim Heinrich,6Josep M Anto,7,8,9,10 Michael J Abramson,11 Anne-Marie Kir of asthma medication and hay fever/nasal allergies increased (0.6%, 95% CI 0.1 to1.11; 3.6%, 95% CI 3.0to 4.2; 2.7%, 95% CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hayfever/nasal allergies at baseline.
CONCLUSIONS: The European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.
上一篇：
学龄前儿童的超重/肥胖（OW）与哮喘恶化相关，但吸入糖皮质激素能显著改善症状
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慢性咳嗽的成人和儿童患者阿诺德神经反射的患病率
