哮喘患者健康相关生活质量：2005与2015两个队列的比较
2017/12/20
摘要
前言：目的是探讨哮喘患者短暂的健康相关生活质量（HRQL）变化和低HRQL的影响因素。
材料和方法：从瑞典小学和哮喘二级护理患者这两个队列中随机抽取患者进行研究，以问卷调查的形式对病人的特征和迷你哮喘生活质量问卷（迷你AQLQ）收集数据，2005年（n = 1034）和2015年（n = 1126）。调整混杂因素后，用T检验和协方差分析比较2005年与2015年迷你AQLQ总分与各领域得分。多变量线性回归分析分析迷你AQLQ评分。
结果：平均Mini AQLQ得分在2005和2015之间没有变化（调整手段（95% CI）2005：5.39（5.27-5.33）和2015（95%可信区间：5.44 5.32至5.38），P = 0.26）。超重（回归系数95%（CI）0.21（-0.36 - 0.07）），肥胖（-0.34（- 0.5 - 0.18）），过去六个月一次或多次的急性加重（-0.64（-0.79 - 0.50）），中度/重度疾病自测（-1.02（-1.15 - 0.89）），心脏病（-0.42（-0.68 - 0.16））、焦虑/抑郁（-0.31（-0.48 - 0.13）），鼻炎（-0.25（-0.42 - 0.08））与低AQLQ相关。较高的教育水平（0.32（0.19-0.46））和急性加重的自我管理及自我报告（0.35（0.19-0.51））与较高的生活质量相关。
结论：过去十年，瑞典哮喘患者健康相关生活质量一般都很好，并保持不变。超重、肥胖，急性加重，中度/重度疾病自测、心脏病、抑郁/焦虑、鼻炎患者与低生活品质相关，高教育水平和自我管理知识与较高的HRQL相关。
Health-related quality of life in asthma patients –Acomparison of two cohorts from 2005 and 2015.
Sundh J, Wireklint P, Hasselgren M3, Montgomery S4, Ställberg B5, Lisspers K6, Janson C7.
Abstract
INTRODUCTION: The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma.
MATERIAL AND METHODS: Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohorts of randomly selected Swedish primary and secondary care asthma patients, in 2005 (n = 1034) and 2015 (n = 1126). Student's t-test and analysis of covariance with adjustment for confounders compared mini-AQLQ total and domain scores in 2005 and 2015. Multivariable linear regression analyzed associations with mini-AQLQ scores.
RESULTS: The mean Mini-AQLQ scores were unchanged between 2005 and 2015 (adjusted means (95% CI) 2005: 5.39 (5.27-5.33) and in 2015: 5.44 (95% CI 5.32 to 5.38), p = 0.26). Overweight (regression coefficient 95% CI) (0.21 (-0.36 to -0.07)), obesity (-0.34 (-0,50 to -0.18)), one or more exacerbations during the previous six months (-0.64 (-0.79 to -0.50)), self-rated moderate/severe disease (-1.02 (-1.15 to -0.89)), heart disease (-0.42 (-0.68 to -0.16)), anxiety/depression (-0.31 (-0.48 to -0.13)) and rhinitis (-0.25 (-0.42 to -0.08)) were associated with lower HRQL. Higher educational level (0.32 (0.19-0.46)) and self-reported knowledge of self-management of exacerbations (0.35 (0.19-0.51)) were associated with higher HRQL.
CONCLUSIONS: HRQL in Swedish patients with asthma is generally good and unchanged during the last decade. Overweight, obesity, exacerbations, self-rated moderate/severe disease, heart disease, depression/anxiety and rhinitis were associated with lower HRQL, and high educational level and knowledge on self-management with higher HRQL.
前言：目的是探讨哮喘患者短暂的健康相关生活质量（HRQL）变化和低HRQL的影响因素。
材料和方法：从瑞典小学和哮喘二级护理患者这两个队列中随机抽取患者进行研究，以问卷调查的形式对病人的特征和迷你哮喘生活质量问卷（迷你AQLQ）收集数据，2005年（n = 1034）和2015年（n = 1126）。调整混杂因素后，用T检验和协方差分析比较2005年与2015年迷你AQLQ总分与各领域得分。多变量线性回归分析分析迷你AQLQ评分。
结果：平均Mini AQLQ得分在2005和2015之间没有变化（调整手段（95% CI）2005：5.39（5.27-5.33）和2015（95%可信区间：5.44 5.32至5.38），P = 0.26）。超重（回归系数95%（CI）0.21（-0.36 - 0.07）），肥胖（-0.34（- 0.5 - 0.18）），过去六个月一次或多次的急性加重（-0.64（-0.79 - 0.50）），中度/重度疾病自测（-1.02（-1.15 - 0.89）），心脏病（-0.42（-0.68 - 0.16））、焦虑/抑郁（-0.31（-0.48 - 0.13）），鼻炎（-0.25（-0.42 - 0.08））与低AQLQ相关。较高的教育水平（0.32（0.19-0.46））和急性加重的自我管理及自我报告（0.35（0.19-0.51））与较高的生活质量相关。
结论：过去十年，瑞典哮喘患者健康相关生活质量一般都很好，并保持不变。超重、肥胖，急性加重，中度/重度疾病自测、心脏病、抑郁/焦虑、鼻炎患者与低生活品质相关，高教育水平和自我管理知识与较高的HRQL相关。
（中日友好医院呼吸与危重症医学科 李红雯 摘译 林江涛 审校 ）
（Respir Med. 2017 Nov;132:154-160. doi: 10.1016/j.rmed.2017.10.010. Epub 2017 Oct 17）
（Respir Med. 2017 Nov;132:154-160. doi: 10.1016/j.rmed.2017.10.010. Epub 2017 Oct 17）
Health-related quality of life in asthma patients –Acomparison of two cohorts from 2005 and 2015.
Sundh J, Wireklint P, Hasselgren M3, Montgomery S4, Ställberg B5, Lisspers K6, Janson C7.
Abstract
INTRODUCTION: The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma.
MATERIAL AND METHODS: Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohorts of randomly selected Swedish primary and secondary care asthma patients, in 2005 (n = 1034) and 2015 (n = 1126). Student's t-test and analysis of covariance with adjustment for confounders compared mini-AQLQ total and domain scores in 2005 and 2015. Multivariable linear regression analyzed associations with mini-AQLQ scores.
RESULTS: The mean Mini-AQLQ scores were unchanged between 2005 and 2015 (adjusted means (95% CI) 2005: 5.39 (5.27-5.33) and in 2015: 5.44 (95% CI 5.32 to 5.38), p = 0.26). Overweight (regression coefficient 95% CI) (0.21 (-0.36 to -0.07)), obesity (-0.34 (-0,50 to -0.18)), one or more exacerbations during the previous six months (-0.64 (-0.79 to -0.50)), self-rated moderate/severe disease (-1.02 (-1.15 to -0.89)), heart disease (-0.42 (-0.68 to -0.16)), anxiety/depression (-0.31 (-0.48 to -0.13)) and rhinitis (-0.25 (-0.42 to -0.08)) were associated with lower HRQL. Higher educational level (0.32 (0.19-0.46)) and self-reported knowledge of self-management of exacerbations (0.35 (0.19-0.51)) were associated with higher HRQL.
CONCLUSIONS: HRQL in Swedish patients with asthma is generally good and unchanged during the last decade. Overweight, obesity, exacerbations, self-rated moderate/severe disease, heart disease, depression/anxiety and rhinitis were associated with lower HRQL, and high educational level and knowledge on self-management with higher HRQL.
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慢性咳嗽的成人和儿童患者阿诺德神经反射的患病率
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长期粗颗粒物暴露与医疗补助儿童的哮喘相关
