关于纤维肌痛综合征作为未控制哮喘病因的多中心病例对照研究
2017/10/23
摘要
背景：当哮喘患者合并纤维肌痛综合征时，纤维肌痛综合征可能影响哮喘的控制
目的：通过描述合并有纤维肌痛综合征的哮喘患者的特点来评估纤维肌痛综合征是否是影响哮喘严重程度及其控制水平的独立危险因素。同时评估此类患者对呼吸困难的感知方式，从而证明对铣刀阻塞感的感知方式变化可能与哮喘控制不佳有关。
方法：这是一项多中心、横断面、病例对照研究。病例组为56名合并纤维肌痛综合征的哮喘患者，对照组为36名哮喘患者，两组在性别、年龄、哮喘严重程度上进行匹配。所有患者均为女性。研究变量为ACT评分、MiniAQLQ评分、奈梅亨过度通气综合征测评表、医院焦虑抑郁评分和气道激发试验后呼吸困难的比例。
结果：尽管两组的哮喘严重程度及用药相当，病例组ACT评分、MiniAQLQ评分较对照组低，焦虑抑郁评分、奈梅亨过度通气综合征测评表较对照组高，所有差异均具有统计学意义。
结论：本研究表明，纤维肌痛综合征影响其道疾病控制，并且与呼吸困难的感知、过度通气综合征、较高的焦虑抑郁发病率具有相关性，影响生活质量。
Fibromyalgia as a cause of uncontrolled asthma: a case–control multicenter study
Eva Martinez-Moragon , Vicente Plaza , Isabel Torres , Ana Rosado , Isabel Urrutia , Xavier Casas ,Belen Hinojosa , Marina Blanco-Aparicio , Julio Delgado , Santiago Quirce , Carles Sabadell , Pilar Cebollero land
Abstract
BACKGROUND:Fibromyalgia can affect the control of asthma when both diseases are present in a single
patient
OBJECTIVE:To characterize asthma in patients with concomitant fibromyalgia to assess whether fibromyalgia is an independent factor of asthma severity that influences poor asthma control. We also evaluated how dyspnea is perceived by patients in order to demonstrate that alterations in the perception of airway obstruction may be responsible for poor asthma control.
METHODS:This was a cross-sectional case–control multicenter study, in which 56 patients in the asthmaand fibromyalgia group were matched to 36 asthmatics by sex, approximate age, and asthma severity level. All patients were women. Study variables included the Asthma Control Test (ACT), the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), the Nijmegen hyperventilation syndrome questionnaire, the Hospital Anxiety and Depression Scale, and perception of dyspnea after acute bronchoconstriction.
RESULTS:Although patients in both study groups showed similar asthma severity and use of anti-asthmatic drugs, patients in the asthma and fibromyalgia group showed lower scores on the ACT and MiniAQLQ questionnaires, and higher scores of anxiety and depression as well as hyperventilation compared to asthma patients without fibromyalgia. All these differences were statistically significant.
CONCLUSIONS:Fibromyalgia in patients with asthma influences poor control of the respiratory disease and is associated with altered perception of dyspnea, hyperventilation syndrome, high prevalence of depression and anxiety, and impaired quality of life.
背景：当哮喘患者合并纤维肌痛综合征时，纤维肌痛综合征可能影响哮喘的控制
目的：通过描述合并有纤维肌痛综合征的哮喘患者的特点来评估纤维肌痛综合征是否是影响哮喘严重程度及其控制水平的独立危险因素。同时评估此类患者对呼吸困难的感知方式，从而证明对铣刀阻塞感的感知方式变化可能与哮喘控制不佳有关。
方法：这是一项多中心、横断面、病例对照研究。病例组为56名合并纤维肌痛综合征的哮喘患者，对照组为36名哮喘患者，两组在性别、年龄、哮喘严重程度上进行匹配。所有患者均为女性。研究变量为ACT评分、MiniAQLQ评分、奈梅亨过度通气综合征测评表、医院焦虑抑郁评分和气道激发试验后呼吸困难的比例。
结果：尽管两组的哮喘严重程度及用药相当，病例组ACT评分、MiniAQLQ评分较对照组低，焦虑抑郁评分、奈梅亨过度通气综合征测评表较对照组高，所有差异均具有统计学意义。
结论：本研究表明，纤维肌痛综合征影响其道疾病控制，并且与呼吸困难的感知、过度通气综合征、较高的焦虑抑郁发病率具有相关性，影响生活质量。
(中日友好医院呼吸与危重症医学科 张科文 摘译 林江涛 审校)
(Current Medical Research and Opinion ISSN: 0300-7995 (Print) 1473-4877 (Online) Journal)
(Current Medical Research and Opinion ISSN: 0300-7995 (Print) 1473-4877 (Online) Journal)
Fibromyalgia as a cause of uncontrolled asthma: a case–control multicenter study
Eva Martinez-Moragon , Vicente Plaza , Isabel Torres , Ana Rosado , Isabel Urrutia , Xavier Casas ,Belen Hinojosa , Marina Blanco-Aparicio , Julio Delgado , Santiago Quirce , Carles Sabadell , Pilar Cebollero land
Abstract
BACKGROUND:Fibromyalgia can affect the control of asthma when both diseases are present in a single
patient
OBJECTIVE:To characterize asthma in patients with concomitant fibromyalgia to assess whether fibromyalgia is an independent factor of asthma severity that influences poor asthma control. We also evaluated how dyspnea is perceived by patients in order to demonstrate that alterations in the perception of airway obstruction may be responsible for poor asthma control.
METHODS:This was a cross-sectional case–control multicenter study, in which 56 patients in the asthmaand fibromyalgia group were matched to 36 asthmatics by sex, approximate age, and asthma severity level. All patients were women. Study variables included the Asthma Control Test (ACT), the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), the Nijmegen hyperventilation syndrome questionnaire, the Hospital Anxiety and Depression Scale, and perception of dyspnea after acute bronchoconstriction.
RESULTS:Although patients in both study groups showed similar asthma severity and use of anti-asthmatic drugs, patients in the asthma and fibromyalgia group showed lower scores on the ACT and MiniAQLQ questionnaires, and higher scores of anxiety and depression as well as hyperventilation compared to asthma patients without fibromyalgia. All these differences were statistically significant.
CONCLUSIONS:Fibromyalgia in patients with asthma influences poor control of the respiratory disease and is associated with altered perception of dyspnea, hyperventilation syndrome, high prevalence of depression and anxiety, and impaired quality of life.
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