正常天气和沙尘天气对伊朗阿瓦士地区健康儿童的呼出气一氧化氮和肺功能影响的比较
2017/07/24
摘要
阿瓦士的沙尘暴所导致的空气污染易对儿童的健康产生不良影响。本研究的目的旨在比较在沙尘天与正常（非沙尘）天的颗粒物质对于小学生健康的损害，把呼出气一氧化氮含量（FENO）和肺功能检查数值作为评价健康损害的指标。研究在阿瓦士的小学生中进行。在沙尘天和正常天，选择不同地区的健康小学生（N=105）进行FENO和肺功能的测量。沙尘天的PM10和PM2.5的数值均高于正常天。正常天气和沙尘天的FENO平均值分别为14.23和20.3ppb，具有统计学显著性差异（P<0.05）。肺功能检查显示沙尘天和正常天的用力肺活量的平均值在统计学上具有显著性差异(P<0.05)。以上结果表明，炎性标志物和肺功能测定值在沙尘天和正常天气两种情况下具有显著差异。基于我们的实验结果，呼出气一氧化氮分数和肺功能测定可以作为颗粒污染效应的短期生物指标。
Comparison of normal and dusty day impacts on fractional exhaled nitric oxide andlung function in healthy children in Ahvaz, Iran.
Neisi A, Vosoughi M, Idani E, et al
Environ Sci Pollut Res Int. 2017 May;24(13):12360-12371. doi:10.1007/s11356-017-8853-4. Epub 2017 Mar 29.
Abstract
Children are the vulnerable group at risk of adverse health effects related to air pollution due to dust storm in Ahvaz. The purpose of this study was to compare the values of fractional exhaled nitric oxide (FENO) and lung functions as parameters of adverse health effects of particulate matter (PM) in dusty and normal (non-dusty) days in elementary schoolchildren. The study was conducted among elementary school students in Ahvaz. The healthy elementary schoolchildren(N = 105) were selected from different districts for FENO and lung function sampling during the dusty and normal days. The values of PM10 and PM2.5 during
dusty days were higher than during normal days. Mean values of FENO during the normal and dusty days were 14.23 and 20.3 ppb, respectively, and the difference between these values was statistically significant (p < 0.05). Lung function results showed a statistically significant difference between the mean values of forced vital capacity during the dusty and normal days (p < 0.05). The results revealed a significant difference both in the values of inflammatory biomarker and in the lung function tests in dusty and normal days. Based on our results,fractional exhaled nitric oxide could be a useful short-term biomarker of particulate pollution effect coupled with spirometry.
DOI: 10.1007/s11356-017-8853-4
PMID: 28357800 [Indexed for MEDLINE]
阿瓦士的沙尘暴所导致的空气污染易对儿童的健康产生不良影响。本研究的目的旨在比较在沙尘天与正常（非沙尘）天的颗粒物质对于小学生健康的损害，把呼出气一氧化氮含量（FENO）和肺功能检查数值作为评价健康损害的指标。研究在阿瓦士的小学生中进行。在沙尘天和正常天，选择不同地区的健康小学生（N=105）进行FENO和肺功能的测量。沙尘天的PM10和PM2.5的数值均高于正常天。正常天气和沙尘天的FENO平均值分别为14.23和20.3ppb，具有统计学显著性差异（P<0.05）。肺功能检查显示沙尘天和正常天的用力肺活量的平均值在统计学上具有显著性差异(P<0.05)。以上结果表明，炎性标志物和肺功能测定值在沙尘天和正常天气两种情况下具有显著差异。基于我们的实验结果，呼出气一氧化氮分数和肺功能测定可以作为颗粒污染效应的短期生物指标。
(复旦大学附属中山医院呼吸科 王晓岑摘译 杨冬审校)
（Environ Sci Pollut Res Int. 2017 May;24(13):12360-12371. doi:10.1007/s11356-017-8853-4. Epub 2017 Mar 29.）
Comparison of normal and dusty day impacts on fractional exhaled nitric oxide andlung function in healthy children in Ahvaz, Iran.
Neisi A, Vosoughi M, Idani E, et al
Environ Sci Pollut Res Int. 2017 May;24(13):12360-12371. doi:10.1007/s11356-017-8853-4. Epub 2017 Mar 29.
Abstract
Children are the vulnerable group at risk of adverse health effects related to air pollution due to dust storm in Ahvaz. The purpose of this study was to compare the values of fractional exhaled nitric oxide (FENO) and lung functions as parameters of adverse health effects of particulate matter (PM) in dusty and normal (non-dusty) days in elementary schoolchildren. The study was conducted among elementary school students in Ahvaz. The healthy elementary schoolchildren(N = 105) were selected from different districts for FENO and lung function sampling during the dusty and normal days. The values of PM10 and PM2.5 during
dusty days were higher than during normal days. Mean values of FENO during the normal and dusty days were 14.23 and 20.3 ppb, respectively, and the difference between these values was statistically significant (p < 0.05). Lung function results showed a statistically significant difference between the mean values of forced vital capacity during the dusty and normal days (p < 0.05). The results revealed a significant difference both in the values of inflammatory biomarker and in the lung function tests in dusty and normal days. Based on our results,fractional exhaled nitric oxide could be a useful short-term biomarker of particulate pollution effect coupled with spirometry.
DOI: 10.1007/s11356-017-8853-4
PMID: 28357800 [Indexed for MEDLINE]
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