颈周径与哮喘之间联系的性别差异
2016/11/09
摘要
简介：肥胖和哮喘控制/生活质量之间的关联通常依赖于身体质量指数（BMI），作为拟人化的措施。由于身体质量指数（BMI）的限制和存在的一些替代措施，如颈周径（NC），我们研究了颈周径和哮喘控制/生活质量之间的关联，特别注意男性女性的差异。
材料和方法：AsthMaP-2项目是关于被医师诊断为哮喘的青少年的观察研究。颈周径按年龄和性别进行分层，研究其与哮喘控制（通过哮喘控制测试[ACT]）和生活质量（通过综合治疗组[ITG]-哮喘简表）的关联。
结果：平均年龄为11.9 ± 3.6 岁，其中53%为男性（N = 116）。平均BMI百分位数为71 ± 28分。31名参与者（27%）符合高颈周径标准。高的颈周径的男性比那些低的颈周径的男性有显著更糟糕的哮喘控制（P = 0.02）和较低的生活质量。女性中没有发现类似的关系，并且ACT和ITG变化的比例能由BMI百分位数给予最好的解释。相反，对男性来说，这些分数的变异的比例用颈周径来解释时变异的比例大于用BMI百分数单独进行解释（Cohen's f(2) = 0.04-0.09，小到中等的规模效应）。
讨论：在男青年哮喘患者中，结合使用颈周径和身体质量指数来解释哮喘控制和生活质量要优于单独使用体重指数来解释。未来对哮喘的研究应包括对测量颈周径和其它区域肥胖的人为措施，来阐明哮喘的性别差异。
（杨冬 审校）
PediatrPulmonol.2016Sep;51(9):893-900.doi:10.1002/ppul.23381. Epub 2016 Jan 15.
Sex differences in the association between neck circumference and asthma.
Maltz L1, Matz EL2, Gordish-Dressman H1,3, Pillai DK1,3,4,5, Teach SJ4,6, Camargo CA Jr7, Hubal MJ1,3, Behniwal S1, Prosper GD1, Certner N1, Marwah R1, Mansell DM1,8, Nwachukwu F1, Lazaroff R1, Tsegaye Y2, Freishtat RJ1,3,4,6.
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Abstract
INTRODUCTION:The association between obesity and asthma control/quality of life commonly relies on body mass index (BMI) as the anthropomorphic measure. Due to limitations of BMI and the existence of alternative measures, such as neck circumference (NC), we examined the association between NC and asthma control/quality of life, with particular attention to male-female differences.
MATERIALS AND METHODS:The AsthMaP-2 Project is an observational study of youth with physician-diagnosed asthma. NC was stratified according to age- and sex-specific cutoffs and associated with asthma control (via Asthma Control Test [ACT]) and quality of life (via Integrated Therapeutics Group [ITG]-Asthma Short Form).
RESULTS:The mean ± SD age was 11.9 ± 3.6 years, and 53% were male (N = 116). The mean BMI percentile was at the 71 ± 28 percentile. Thirty-one participants (27%) met criteria for high NC. Males with high NC had significantly worse asthma control (P = 0.02) and lower quality of life than those with low NC. No similar association was found for females and the proportion of variability in ACT and ITG was best explained by BMI percentile. Conversely, for males, the proportion of variability in these scores explained by NC was larger than BMI percentile alone (Cohen's f(2) = 0.04-0.09, a small to medium effect size).
DISCUSSION:Among male youth with asthma, combined use of NC and BMI percentile explained asthma control and quality of life better than BMI alone. Future studies of asthma should include measurement of NC and other anthropogenic measures of regional adiposity to clarify sex differences in asthma. Pediatr Pulmonol. 2016; 51:893-900. © 2016 Wiley Periodicals, Inc.
© 2016 Wiley Periodicals, Inc.
KEYWORDS:adiposity; body mass index; pediatric obesity; pediatrics
PediatrPulmonol.2016Sep;51(9):893-900.doi:10.1002/ppul.23381. Epub 2016 Jan 15.
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