电子烟的使用对急切想咳嗽感觉的影响
2016/10/09
摘要
简介：电子烟（e-cigs）已经在世界范围内普遍使用，但对其生理效应的认识仍然很少。本研究的目的是评估在单次暴露于电子烟蒸汽中对急切想咳嗽（UTC）阈值和C5的影响。
方法：17例健康的非吸烟者在电子烟暴露后（30次电子烟蒸汽吸入，每次间隔时间为30秒）分别在在基线、15分钟、24小时后用辣椒素激发咳嗽，进行C5测量。咳嗽激发的终点是C5，辣椒素的浓度诱导五次或五次以上咳嗽。UTC的阈值（Cu）定义为辣椒素诱导UTC没有相关真正咳嗽的最低浓度。
结果：在吸电子烟后15分钟UTC的阈值（Cu）和C5均明显地被抑制（Cu和C5增加）。平均log Cu 从- 0.035±0.08（SEM）上升至0.21±0.12（P = 0.005）。平均log C5从0.60±0.11增加到0.92±0.16（P = 0.001）。电子烟暴露24小时后，Cu和C5回到基线水平。
结论：单独一段时间电子烟的使用，接近一根纸烟尼古丁量的时候，引起了Cu和C5的显著抑制。以前的研究表明尼古丁导致了C5被抑制，我们假设尼古丁Cu上具有类似的抑制作用。考虑到我们观察到的单次电子烟的暴露效果，对反复或慢性电子烟使用对呼吸生理影响的研究是必要的。
提示：这是通过辣椒素咳嗽激发测试实验阐明暴露于电子烟可显著抑制Cu的首次研究。这些发现进一步表明，电子烟蒸气不是生理上的良性物质，支持对反复或慢性电子烟使用对咳嗽敏感性和其他呼吸参数的影响的进一步研究。
（苏欣 审校）
NicotineTobRes.2016Aug;18(8):1763-5.doi: 10.1093/ntr/ntw021. Epub 2016 Jan 22.
Effect of Electronic Cigarette Use on the Urge-to-Cough Sensation.
Dicpinigaitis PV1, Lee Chang A2, Dicpinigaitis AJ2, Negassa A2.
Author information
Abstract
INTRODUCTION:Electronic cigarettes (e-cigs) have attained common usage worldwide, yet knowledge of their physiological effects remains minimal. The aim of this study was to evaluate the effect of a single exposure to e-cig vapor on the urge-to-cough (UTC) threshold and C5.
METHODS:Seventeen healthy nonsmokers underwent C5 measurement employing capsaicin cough challenge at baseline, 15 minutes, and 24 hours after e-cig exposure (30 puffs 30 seconds apart). The endpoint of cough challenge is C5, the concentration of capsaicin inducing five or more coughs. The UTC threshold (Cu) is defined as the lowest concentration of capsaicin inducing UTC without an associated motor cough.
RESULTS:The Cu and C5 were significantly inhibited (Cu and C5 increased) 15 minutes after e-cig use. Mean log Cu rose from -0.035±0.08 (SEM) to 0.21±0.12 (P = .005). Mean log C5 increased from 0.60±0.11 to 0.92±0.16 (P = .001). By 24 hours after e-cig exposure, Cu and C5 had returned to baseline levels.
CONCLUSIONS:A single session of e-cig use, approximating nicotine exposure of one tobacco cigarette, induces significant inhibition of the Cu, as well as C5. Previous studies implicate nicotine as the agent responsible for suppression of C5, and we hypothesize a similar role for nicotine in the suppression of the Cu. Given our observation of the effect of a single e-cig exposure, studies of the respiratory physiologic implications of repeated or chronic e-cig use are warranted.
IMPLICATIONS:This is the first study to demonstrate that a single exposure to an e-cig significantly inhibits the Cu as measured by capsaicincough challenge testing. These findings add to the growing body of evidence that e-cig vapor is not a physiologically benign substance, and support further investigation of the effects of repeated or chronic use of e-cigs on cough sensitivity and other respiratory parameters.
© The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
NicotineTobRes.2016Aug;18(8):1763-5.doi: 10.1093/ntr/ntw021. Epub 2016 Jan 22.
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