豚鼠模型哮喘进展过程中肺音的变化
2016/10/09
摘要
背景：肺音分析在客观评价气道上是有用的，即使是儿童无症状性哮喘。然而，肺音和气道形态变化之间的关系还没有阐明。我们研究了豚鼠在哮喘的发展过程中，肺音和气道慢性形态改变之间的关系。
方法：对11只雄性豚鼠进行了检查，其中7只被用作哮喘模型，4只作为对照。哮喘模型致敏并反复用吸入性鸡卵清白蛋白进行刺激。我们测量肺音和肺功能，每周两次，为期21周。最后一次抗原激发后，肺被切下进行组织学检查。我们测量气道壁厚度与气道总面积的比率，和内部面积与气管、第三支气管和终末细支气管的总气道面积的比率。
结果：在肺部的声音方面，两组之间的差异是最大的是吸气时的音量强度。与对照组相比，气道壁厚度与终末细支气管的气道总面积的比值在哮喘模型中更大，与它最为相关的的是范围在501-1000-Hz之间的吸气声音强度的变化（r = 0.76，P＜0.003）。
结论：从501到1000Hz的中频肺音强度与外周气道壁厚度相关。吸气音的强度似乎是哮喘小气道形态变化的一个指标。
（苏欣 审校）
AllergolInt. 2016 Aug 4.pii:S1323-8930(16)30032-6.doi:10.1016/j.alit.2016.03.010. [Epub ahead of print]
Changes in lung sounds during asthma progression in a guinea pig model.
Habukawa C1, Murakami K2, Sugitani K3, Ohtani T3, Saputra GP3, Kashiyama K3, Nagasaka Y4, Wada S3.
Author information
Abstract
BACKGROUND:Lung sound analysis is useful for objectively evaluating airways even in children with asymptomatic asthma. However, the relationship between lung sounds and morphological changes in the airways has not been elucidated. We examined the relationship between lung sounds and chronic morphological changes in the airways during the progression of asthma from onset in guinea pigs.
METHODS:Eleven male guinea pigs were examined; of these, seven were used as asthma models and four as controls. The asthma models were sensitized and repeatedly challenged by inhaling albumin chicken egg. We measured lung sounds and lung function twice a week for 21 weeks. After the final antigen challenge, the lungs were excised for histological examination. We measured the ratio of airway wall thickness to the total airway area and the ratio of the internal area to the total airway area in the trachea, third bronchi, and terminal bronchioles.
RESULTS:Among the lungs sounds, the difference between the two groups was greatest with respect to inspiratory sound intensity. The ratio of airway wall thickness to the total airway area of the terminal bronchioles was greater in the asthma models than in the controls, and it correlated best with the changes in inspiratory sound intensity in the 501-1000-Hz range (r = 0.76, p < 0.003).
CONCLUSIONS:Lung sound intensity in the middle frequency range from 501 to 1000 Hz correlated with peripheral airway wall thickness. Inspiratory sound intensity appeared to be an indicator of morphological changes in small airways in asthma.
Copyright © 2016 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.
KEYWORDS:Asthma; Bronchi; Guinea pigs; Lung; Respiratory sounds
AllergolInt. 2016 Aug 4.pii:S1323-8930(16)30032-6.doi:10.1016/j.alit.2016.03.010. [Epub ahead of print]
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产前和产后的压力和儿童哮喘：时间和性别的关系
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哮喘-COPD重叠综合征（ACOS）与“纯”COPD相比：有独特的表型？
