在哮喘和慢性阻塞性肺病患者中自身抗体谱和他们与血嗜酸性粒细胞的关系
2016/10/09
摘要
背景：自身免疫性参与哮喘和慢性阻塞性肺疾病（COPD）的发病机制已被提出，自身抗体是自身免疫性疾病的一个标志。本研究旨在比较哮喘和慢性阻塞性肺疾病的自身抗体谱，以及自身抗体与这些疾病的特征之间的关系。
方法：我们招募了110名哮喘患者和92名慢性阻塞性肺病患者进行前瞻性研究。对六类自身抗体类型进行了评估：抗核抗体、抗胞浆抗体、类风湿因子、抗环瓜氨酸肽抗体，髓过氧化物酶抗中性粒细胞胞浆抗体（MPO-ANCA）和蛋白酶3-ANCA。同时记录其它临床数据。
结果：对≥1:160抗核抗体滴度仅在哮喘患者中发现，但在慢性阻塞性肺疾病中没有发现（10% VS. 0%，P = 0.0002）。血液中嗜酸性粒细胞在哮喘的抗核抗体中显示为阴性预测因子。相反，在血液中的嗜酸性粒细胞计数与≥100 IU/mL免疫球蛋白E水平均与哮喘而非COPD中的类风湿因子呈现正相关。抗核抗体或类风湿因子和疾病的严重程度无关。
结论：很可能哮喘比COPD往往涉及抗核抗体的自身免疫更常见，因为哮喘是抗核抗体阳性的更强大的因素。抗核抗体和类风湿因子和嗜酸性粒细胞反应有关，但他们不能作为疾病严重程度的生物标志物。
关键词：抗体；哮喘；慢性阻塞性肺疾病；嗜酸性粒细胞；类风湿因子
（杨冬 审校）
Allergol Int.2016Aug31.pii: S1323-8930(16)30112-5.doi:10.1016/j.alit.2016.08.005. [Epub ahead of print]
Autoantibody profiles and their association with blood eosinophils in asthma and COPD.
Tamai K1, Yoshimatsu H2, Saito T3, Matsuoka H2, Okada N2, Koma Y2, Otsuka A2, Oda N2, Inoue S2, Kume S2, Suzuki Y2.
Author information
Abstract
BACKGROUND:Autoimmune involvement in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been proposed, and autoantibodies are a hallmark of autoimmunity. This study aimed to compare the autoantibody profiles of asthma and COPD, and the relationship between autoantibodies and features of these diseases.
METHODS:We recruited 110 asthma patients and 92 COPD patients for a prospective study. Six autoantibody types were evaluated: antinuclear antibody, anti-cytoplasmic antibodies, rheumatoid factor, anti-cyclic citrullinated peptide antibody, myeloperoxidase-anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) and proteinase 3-ANCA. Other clinical data were also recorded concurrently.
RESULTS:An antinuclear antibody titre of ≥1:160 presented only in asthma but not in COPD (10% vs. 0%, p = 0.0002). Eosinophil counts in blood were negative predictors of antinuclear antibody in asthma. Conversely, eosinophil counts in blood and immunoglobulin-E levels of ≥100 IU/mL were positively associated with rheumatoid factor in asthma but not in COPD. There was no relationship between antinuclear antibody or rheumatoid factor and disease severity.
CONCLUSIONS:It is possible that asthma tends to involve autoimmunity associated with antinuclear antibody more frequently than COPD because asthma is the more robust factor for antinuclear antibody positivity. Antinuclear antibody and rheumatoid factor are associated with eosinophilic responses, but they do not work as biomarkers for disease severity.
Copyright © 2016 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.
KEYWORDS:Antibody; Asthma; Chronic obstructive pulmonary disease; Eosinophils; Rheumatoid factor
Allergol Int.2016Aug31.pii: S1323-8930(16)30112-5.doi:10.1016/j.alit.2016.08.005. [Epub ahead of print]
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食品和吸入性变应原致敏在成人嗜酸性粒细胞性食管炎中的作用
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通过G蛋白调控AGS3蛋白基肽的气道炎症的调控
