大剂量舌下变应原免疫治疗的不良反应和耐受性
2016/08/31
摘要
背景：舌下变应原免疫治疗对过敏性呼吸道疾病是一种有效的方法。许多研究表明了这种疗法是安全的，虽然可能会影响大剂量舌下免疫耐受性的因素没有完全弄清楚。本研究的目的是确定影响舌下变应原免疫治疗耐受性的因素。
病人和方法：共有183名5岁以上受试者参加了这项开放的、回顾性、多中心、非干预性研究，这些受试者由于对草、橄榄花粉或螨过敏被确诊为过敏性鼻炎伴/不伴轻度到中度致敏哮喘。舌下免疫治疗给药至少3个月。
结果：最常见的不良反应为口腔瘙痒（13.7%的患者）。大多数的反应是局部瘙痒（84.7%）和立即瘙痒（93.5%），并发生在起始阶段（60.6%）。所有反应的严重程度是轻度至中度。无严重不良反应发生。当比较与不良反应的发生可能有关的影响因素时，有或者没有不良反应的患者组之间的结果表现出：性别（P = 0.6417）、年龄（P = 0.1801）、发病时间（P = 0.3800），处理组合（P = 0.6946）多致敏情况（P = 0.1730）或临床诊断（P = 0.3354）均无统计学上的显著差异。然而，治疗持续时间有统计学上显着的影响（3个月，> 3个月：P = 0.0442），哮喘的存在是接近具有统计学意义（P = 0.0847）。
结论：在我们的研究中，治疗时间与高剂量舌下变应原免疫治疗给药后有不良反应的发生显著相关。
(杨冬 审校)
J Asthma Allergy. 2016 Jun 29;9:129-33.doi:10.2147/JAA.S107830.eCollection 2016.
Adverse reactions and tolerability of high-dose sublingual allergen immunotherapy.
Moral A1, Moreno V2, Girón F3, El-Qutob D4, Moure JD5, Alcántara M6, Padial A7, Oehling AG8, Millán C9, de la Torre F10.
Author information
Abstract
BACKGROUND:Sublingual allergen immunotherapy is an effective treatment against allergic respiratory disease. Many studies have shown the safety of this type of therapy, although the factors that might affect the tolerability of high-dose sublingual immunotherapy have not been well established. The aim of this study was to determine the factors that affect the tolerability of sublingual allergen immunotherapy.
PATIENTS AND METHODS:A total of 183 subjects aged ≥5 years, diagnosed with allergic rhinitis with/without mild to moderate asthma due to sensitization to grass, olive pollen, or mites, were included in this open, retrospective, multicentric, noninterventional study. Sublingual immunotherapy was administered for at least 3 months.
RESULTS:The most frequent adverse reaction was oral pruritus (13.7% of the patients). Most of the reactions were local (84.7%) and immediate (93.5%) and occurred during the initiation phase (60.6%). All reactions were mild to moderate in severity. No serious adverse reactions were registered. When comparing factors with potential influence on the occurrence of adverse reactions, the results between the groups of subjects with and without adverse reactions showed no statistically significant differences in sex (P=0.6417), age (P=0.1801), years since the disease was first diagnosed (P=0.3800), treatment composition (P=0.6946), polysensitization (P=0.1730), or clinical diagnosis (P=0.3354). However, it was found that treatment duration had a statistically significant influence (3 months, >3 months: P=0.0442) and the presence of asthma was close to statistical significance (P=0.0847).
CONCLUSION:In our study, treatment duration is significantly associated with the occurrence of adverse reactions after the administration of high doses of sublingual allergen immunotherapy.
J Asthma Allergy. 2016 Jun 29;9:129-33.doi:10.2147/JAA.S107830.eCollection 2016.
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对牛奶过敏的儿童用微波加热牛奶进行两周持续口服免疫耐受治疗
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对哮喘持续状态的孕妇使用救命的体外膜肺氧合（ECMO）
