大量饮酒导致高IgE水平但过敏性疾病的风险不高
2016/08/31
摘要
背景：大量饮酒在观察性研究中被发现与高的免疫球蛋白E（IgE）水平相关；然而，大量饮酒是否会导致高的IgE水平与过敏性疾病还不清楚。
目的：我们测试这一假设：大量饮酒与高IgE水平与过敏性疾病在观测性研究和使用无反向因果关系和基本没有混杂因素的孟德尔随机化设计的遗传学研究中均相关。
方法：111408名年龄从20到100岁的人群中，有50019个人有血浆IgE值测量结果，对102270个人进行酒精代谢酶乙醇脱氢酶1B（ADH-1B；rs1229984）和乙醇脱氢酶1C（ADH-1C；rs698）进行了基因型测定。通过观察，我们研究了IgE水平与过敏性疾病（过敏性哮喘、过敏性鼻炎，和湿疹）的相互关系，以及饮酒和IgE水平与过敏性疾病之间的相互关系。在遗传学方面，我们探讨饮酒与IgE水平和过敏性疾病之间潜在的因果关系。
结果：多变量校正后的IgE大于150 kU/L与小于150 kU/L的比值比，与无过敏性疾病的受试者相比：1种过敏性疾病为2.3（95% CI，2.2-2.5），2种过敏性疾病为3.9（95% CI，3.5～4.4），3种过敏性疾病为7.5（95% CI，6.2-9.0）。大量饮酒和高IgE水平相关，但不与过敏性疾病的高风险相关。高与低的IgE水平每一种酒精饮料每周的比值比为：较大量饮酒的遗传上为1.12（95% CI，1.02-1.23），观测中为1.01（95% CI，1.01-1.02）；对过敏性疾病，相应的比值比分别为0.96（95% CI，71）和1.00（95% CI，1.00-1.00）。
结论：大量饮酒与高IgE水平在观测中和遗传上都相关，但不与过敏性疾病的高风险相关。
（杨冬 审校）
J Allergy Clin Immunol. 2016 Jun 23. pii: S0091-6749(16)30520-6. doi: 10.1016/j.jaci.2016.05.022. [Epub ahead of print]
High alcohol consumption causes high IgE levels but not high risk of allergic disease.
Lomholt FK1, Nielsen SF1, Nordestgaard BG2.
Author information
Abstract
BACKGROUND:High alcohol consumption is associated with high IgE levels in observational studies; however, whether high alcohol consumption leads to high IgE levels and allergic disease is unclear.
OBJECTIVE:We tested the hypothesis that high alcohol consumption is associated with high IgE levels and allergic disease both observationally and genetically using a Mendelian randomization design free of reverse causation and largely free of confounding.
METHODS:Among 111,408 subjects aged 20 to 100 years from the general population, 50,019 had plasma IgE measurements, and 102,270 were genotyped for the alcohol-metabolizing enzymes alcohol dehydrogenase 1B (ADH-1B; rs1229984) and alcohol dehydrogenase 1c (ADH-1C; rs698). Observationally, we investigated associations between IgE levels and allergic disease (allergic asthma, rhinitis, and eczema) and between alcohol consumption and IgE levels and allergic disease. Genetically, we explored potential causal relationships between alcohol consumption and IgE levels and allergic disease.
RESULTS:The multivariable adjusted odds ratio for IgE levels greater than versus less than 150 kU/L and compared with subjects without allergic disease was 2.3 (95% CI, 2.2-2.5) for 1 allergic disease, 3.9 (95% CI, 3.5-4.4) for 2 allergic diseases, and 7.5 (95% CI, 6.2-9.0) for 3 allergic diseases. High alcohol consumption was associated with high IgE levels but not with high risk of allergic disease. The odds ratio for high versus low IgE levels per 1 alcoholic drink per week higher consumption was 1.12 (95% CI, 1.02-1.23) genetically and 1.01 (95% CI, 1.01-1.02) observationally; for allergic disease, the corresponding odds ratios were 0.96 (95% CI, 0.92-1.00) genetically and 1.00 (95% CI, 1.00-1.00) observationally.
CONCLUSION:High alcohol consumption is associated observationally and genetically with high IgE levels but not with high risk of allergic disease.
Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
KEYWORDS:Ethanol; IgE; Mendelian randomization; alcohol dehydrogenase; asthma; eczema; general population; rhinitis
J Allergy Clin Immunol. 2016 Jun 23. pii: S0091-6749(16)30520-6. doi: 10.1016/j.jaci.2016.05.022. [Epub ahead of print]
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妊娠期使用抗生素和学龄前儿童哮喘：混杂因素的影响
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在妊娠期暴露于室外空气污染和儿童哮喘、过敏性鼻炎、湿疹
