尿中金属浓度与成人哮喘的相关性研究——中国武汉市的病例对照研究
2016/07/27
摘要
背景:据报道，一些金属与儿童哮喘有关。然而，金属和儿童哮喘的风险之间的关系仍未有定论，对中国普通人群中成人哮喘的研究是罕见的。
目的：研究尿液中金属水平与成人哮喘之间的潜在联系。
方法：在中国武汉市开展了一项551例成人哮喘病例和551例性别和年龄匹配的对照组的病例-对照研究。获得人口信息，评估肺功能。用电感耦合等离子体质谱法测定尿中22种金属的浓度。
结果：对其他金属和其他协变量进行校正后，尿镉、钼、铬、铜、铀和硒与哮喘呈正相关，比值比（95%置信区间）分别为1.69（1.00，2.85）、3.76（2.30，6.16）、4.89（3.04，7.89）、6.06（3.27，11.21）、6.99（4.37、11.19）和9.17（4.16，20.21）。相比之下，尿铅、钡、铁、锌、镍、锰和铷与哮喘呈负相关，比值比（95%置信区间）分别为0.48（0.29，0.80）、0.44（0.27，0.71）、0.41（0.26，0.64）、0.40（0.24，0.66）、0.30（0.22，0.41）），0.23（0.14，0.39）和0.07（0.03，0.15）。与对照组相比，当比较不同的亚组中尿液中金属时，以上13种金属与哮喘患病率的关联几乎是相同的。
结论：我们的研究结果表明，中国成人哮喘患病率与尿铬、铬、硒、钼、镉、和铀呈正相关，与尿锰、铁、镍、锌、铷、钡和铅呈负相关。需要开展不同区域、更大规模病例的额外研究来支持我们的研究结果。
（苏欣 审校）
PLoS One. 2016 May 18;11(5):e0155818. doi: 10.1371/journal.pone.0155818. eCollection 2016.
Association between Concentrations of Metals in Urine and Adult Asthma: A Case-Control Study in Wuhan, China.
Huang X1, Xie J2, Cui X1, Zhou Y1, Wu X2, Lu W1, Shen Y1, Yuan J1, Chen W1.
Author information
Abstract
BACKGROUND:Several metals have been reported to be associated with childhood asthma. However, the results on relationships between metals and risk of childhood asthma are inconclusive, and the research on adult asthma in the Chinese general population is rare.
OBJECTIVES:To investigate potential associations between levels of urinary metals and adult asthma.
METHODS:A case-control study of 551 adult asthma cases and 551 gender- and age-matched controls was conducted in Wuhan, China. Demographic information was obtained, and lung function was assessed. The urinary concentrations of 22 metals were measured by inductively coupled plasma mass spectrometry.
RESULTS:After adjusting for other metalsand other covariates, urinary cadmium, molybdenum, chromium, copper, uranium and selenium were positively associated with asthma, with odds ratios (95% CI) of 1.69 (1.00, 2.85), 3.76 (2.30, 6.16), 4.89 (3.04, 7.89), 6.06 (3.27, 11.21), 6.99 (4.37, 11.19) and 9.17 (4.16, 20.21), respectively. By contrast, urinary lead, barium, iron, zinc, nickel, manganese and rubidium were negatively associated with asthma, with odds ratios (95% CI) of 0.48 (0.29, 0.80), 0.44 (0.27, 0.71), 0.41 (0.26, 0.64), 0.40 (0.24, 0.66), 0.30 (0.22, 0.41), 0.23 (0.14, 0.39) and 0.07 (0.03, 0.15), respectively. When comparing urinary metals in different subgroups of cases with those in matched controls, the associations of above 13 metals with asthma prevalence were nearly the same.
CONCLUSIONS:Our results suggested that asthma prevalence in the Chinese adults was positively associated with urinary chromium, chromium, selenium, molybdenum, cadmium, and uranium, and negatively associated with urinary manganese, iron, nickel, zinc, rubidium, barium and lead. Additional research with larger populations in different regions is required to support our findings.
PLoS One.2016 May 18;11(5):e0155818. doi: 10.1371/journal.pone.0155818. eCollection 2016.
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