胃食管动力障碍与咳嗽变异性哮喘患者咳嗽相关的生活质量损害相关嗽变异性哮喘患者胃动力障碍与
2016/06/20
摘要
背景：胃食管反流病（GERD）是哮喘和慢性咳嗽的常见合并症。我们对胃食管反流病的症状对哮喘咳嗽患者咳嗽相关的生活质量（QoL）的影响是知之甚少。本研究的目的是使用莱斯特咳嗽问卷调查（LCQ）来确定GERD症状与咳嗽变异性哮喘（CVA）患者咳嗽相关的生活质量相互关系。
方法：总共有172例（121例女性）平均持续咳嗽时间为45.1个月的持续咳嗽患者（范围2-480月）完成了日本版的莱斯特咳嗽问卷调查（LCQ）。胃食管反流症状的频率量表用来评估酸反流和运动功能障碍的症状。评估了一系列可以确定咳嗽相关性生活质量的临床变量。
结果：平均莱斯特咳嗽问卷调查（LCQ）评分为12.9（SD 3.5），与生活质量严重损害一致。单变量回归分析显示女性、胃食管动力障碍症状、过敏原（屋尘和日本雪松花粉）致敏和致敏的过敏原数量与LCQ评分（即咳嗽的相关性的生活质量受损）较低相关。酸反流症状、气道高反应性、部分呼出气一氧化氮和霉菌致敏与LCQ评分无关。校正了性别之后，胃食管动力障碍症状是咳嗽相关生活质量受损的唯一决定因素，变异量为23%。
结论：咳嗽相关的生活质量严重影响了咳嗽变异性哮喘患者。胃食管动力障碍症状是咳嗽变异性哮喘患者咳嗽相关生活质量的独立预测因素。
（苏欣 审校）
AllergolInt. 2016 Apr 4.pii:S1323-8930(16)30008-9.doi:10.1016/j.alit.2016.02.014. [Epub ahead of print]
Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients withcough variant asthma.
Kanemitsu Y1, Niimi A2, Matsumoto H3, Iwata T3, Ito I3, Oguma T3, Inoue H3, Tajiri T3, Nagasaki T3, Izuhara Y3, Petrova G3, Birring SS4, Mishima M3.
Author information
Abstract
BACKGROUND:Gastroesophageal reflux disease (GERD) is known as a common comorbidity of asthma and chronic cough. The impact of GERD symptoms on cough-specific quality of life (QoL) in patients with asthmatic cough is poorly understood. The aim of this study is to determine the association of GERD symptoms with cough-specific quality of life in patients with cough variant asthma (CVA) using the Leicester CoughQuestionnaire (LCQ).
METHODS:A total of 172 consecutive patients (121 females) with mean cough duration of 45.1 months (range 2-480 months) completed the Japanese version of the LCQ. The Frequency Scale for the Symptoms of Gastroesophageal reflux was administered to assess symptoms of acid-reflux and dysmotility. A range of clinical variables that may determine cough-specific QoL (LCQ) were estimated.
RESULTS:The mean LCQ scores was 12.9 (SD 3.5), consistent with severe impairment in QoL. Female gender, symptoms of gastroesophageal dysmotility, sensitization to allergens (house dust and Japanese cedar pollen) and the number of sensitized allergens were associated with lower LCQ scores (i.e. impaired cough-specific QoL) in univariate regression analysis. Acid-reflux symptoms, airway hyperresponsiveness, fractional exhaled nitric oxide, and sensitization to molds were unrelated to the LCQ score. After adjustment for gender, symptoms of gastroesophageal dysmotility was the only significant determinant of impaired cough-specific QoL accounting for 23% of the variance.
CONCLUSIONS: Cough-specific QoL is severely impaired in patients with CVA. Symptoms of gastroesophageal dysmotility are an independent predictor of cough-specific QoL of patients with CVA.
Copyright © 2016 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.
KEYWORDS: Chronic cough; Cough variant asthma; Gastroesophageal dysmotility; Quality of life; The Leicester Cough Questionnaire
AllergolInt. 2016 Apr 4.pii:S1323-8930(16)30008-9.doi:10.1016/j.alit.2016.02.014. [Epub ahead of print]
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肺结核患者咳嗽频率的研究报告
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