GSTs的变异能改变交通空气污染和青少年哮喘之间的关联吗？
2016/06/20
摘要
参与氧化应激反应的基因多态性可能部分解释暴露在交通有关的空气污染（TRAP）与儿童哮喘和过敏之间相关及其异质性。我们研究GSTT1，GSTM1和GSTP1的基因多态性是否对婴儿第一年所受的交通所致的空气污染和青少年时期的哮喘、喘息和干草热之间的关联有影响。我们从墨尔本特应性队列研究中选出了620个高风险婴儿作为我们的出生队列研究对象。婴儿第一年所受的交通所致的空气污染被设定为在第一年每个研究对象住处150米范围内的主要道路的累积长度。喘息、哮喘和干草热在12岁（n = 370）和18（n = 434）岁时评定。
对谷胱甘肽S-转移酶（GSTs）的相互联系和相互作用进行了回归模型的研究。总的来说，第一年暴露在交通所致的空气污染与12岁或者18岁时的哮喘、喘息和干草热无关。然而，在GSTT1缺失的患儿中，第一年暴露在主道路累积长度每增加100米，在12岁时患喘息的风险要增加2.31倍，患哮喘的风险要增加2.15倍。交通所致的空气污染（TRAP）与一些呼吸疾病相关，是由于氧化应激代谢基因遗传多态性而致。
（杨冬 审校）
Int J Mol Sci. 2016 Apr 1;17(4). pii: E485. doi: 10.3390/ijms17040485.
Do Variants in GSTs Modify the Association between Traffic Air Pollution and Asthma in Adolescence?
Bowatte G1, Lodge CJ2,3, Lowe AJ4,5, Erbas B6, Dennekamp M7, Marks GB8,9, Perret J10, Hui J11, Wjst M12, Gurrin LC13, Allen KJ14,15, Abramson MJ16,Matheson MC17, Dharmage SC18,19.
Author information
Abstract
Polymorphisms in genes involved in the oxidative stress response may partially explain the documented heterogeneous associations between traffic-related air pollution (TRAP) exposure and asthma and allergies in children. We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence. We used a birth cohort of 620 high risk infants from the Melbourne Atopy Cohort Study. TRAP exposure during the first year of life was defined as the cumulative length of major roads within 150 m of each participant's residence during the first year of life. Wheeze, asthma and hay fever were measured at ages 12 (n = 370) and 18 (n = 434) years. The associations and interactions with glutathione S-transferases (GST s) were investigated using regression models. Overall, there was no relationship between TRAP exposure during the first year of life and current asthma, wheeze and hay fever at ages 12 or 18 years. However, in GSTT1 null carriers, every 100 m increase in cumulative lengths of major road exposure during the first year of life was associated with a 2.31-fold increased risk of wheeze and a 2.15-fold increased risk of asthma at 12 years. TRAP is associated with some respiratory outcomes in carriers of genetic polymorphisms in oxidative stress metabolism genes.
KEYWORDS:asthma; glutathione S-transferase; hay fever; traffic related air pollution; wheeze
Int J Mol Sci. 2016 Apr 1;17(4). pii: E485. doi: 10.3390/ijms17040485.
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