胃动力障碍与咳嗽变异型哮喘患者的咳嗽相关的生活质量的损害相关
2016/06/20
摘要
背景：胃食管反流病（GERD）是哮喘和慢性咳嗽的常见合并症。胃食管反流病的症状对具有哮喘性咳嗽患者的咳嗽相关的生活质量（QoL）的影响是知之甚少。本研究旨在采用莱斯特咳嗽问卷（LCQ）来确定胃食管反流病（GERD）的症状与咳嗽变异型哮喘患者的咳嗽相关的生活质量（QoL）之间的关系。
方法：总共有172例患者（121例女性患者）完成了日文版的LCQ问卷调查，他们平均咳嗽持续时间为45.1个月的（范围2-480月）。胃食管反流症状的频率量表来评估酸反流和动力障碍的症状。估算出可以用来确定咳嗽变异型哮喘患者的咳嗽相关的生活质量（LCQ）的临床变量范围。
结果：平均LCQ评分为12.9（SD 3.5），与生活质量有严重损害一致。在单因素回归分析中，女性、胃动力障碍症状、对过敏源的敏感性（屋尘和日本雪松花粉）和致敏的过敏原的数量与低生活质量评分相关（即咳嗽相关的生活质量受损）。酸反流症状，气道高反应性、呼出气一氧化氮，和霉菌致敏等与LCQ评分无关。在校正了性别因素之后，胃动力障碍症状是咳嗽生活质量的唯一重要决定因素，占到23%。
结论：咳嗽相关的生活质量在咳嗽变异型哮喘患者（CVA）中受到严重影响。胃动力障碍症状是CVA患者咳嗽相关生活质量的独立预测因子。
（杨冬 审校）
AllergolInt. 2016 Apr 4.pii:S1323-8930(16)30008-9.doi:10.1016/j.alit.2016.02.014. [Epub ahead of print]
Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma.
Kanemitsu Y1, Niimi A2, Matsumoto H3, Iwata T3, Ito I3, Oguma T3, Inoue H3, Tajiri T3, Nagasaki T3, Izuhara Y3, Petrova G3, Birring SS4, Mishima M3.
Author information
Abstract
BACKGROUND:Gastroesophageal reflux disease (GERD) is known as a common comorbidity of asthma and chronic cough. The impact of GERD symptoms on cough-specific quality of life (QoL) in patients with asthmatic cough is poorly understood. The aim of this study is to determine the association of GERD symptoms with cough-specific quality of life in patients with cough variant asthma (CVA) using the Leicester Cough Questionnaire (LCQ).
METHODS:A total of 172 consecutive patients (121 females) with mean cough duration of 45.1 months (range 2-480 months) completed the Japanese version of the LCQ. The Frequency Scale for the Symptoms of Gastroesophageal reflux was administered to assess symptoms of acid-reflux and dysmotility. A range of clinical variables that may determine cough-specific QoL (LCQ) were estimated.
RESULTS:The mean LCQ scores was 12.9 (SD 3.5), consistent with severe impairment in QoL. Female gender, symptoms of gastroesophageal dysmotility, sensitization to allergens (house dust and Japanese cedar pollen) and the number of sensitized allergens were associated with lower LCQ scores (i.e. impaired cough-specific QoL) in univariate regression analysis. Acid-reflux symptoms, airway hyperresponsiveness, fractional exhaled nitric oxide, and sensitization to molds were unrelated to the LCQ score. After adjustment for gender, symptoms of gastroesophageal dysmotility was the only significant determinant of impaired cough-specific QoL accounting for 23% of the variance.
CONCLUSIONS:Cough-specific QoL is severely impaired in patients with CVA. Symptoms of gastroesophageal dysmotility are an independent predictor of cough-specific QoL of patients with CVA.
Copyright © 2016 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.
KEYWORDS:Chronic cough; Cough variant asthma; Gastroesophageal dysmotility; Quality of life; The Leicester Cough Questionnaire
AllergolInt. 2016 Apr 4.pii:S1323-8930(16)30008-9.doi:10.1016/j.alit.2016.02.014. [Epub ahead of print]
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