哮喘发病的年龄和环境空气污染的脆弱性：来自台湾南部的成年人的一项观察性研究
2016/06/20
摘要
背景：迟发型哮喘（发病 > 12年）在病理上不同于早发型哮喘。空气污染这一机制不是一个典型的过敏性炎症、可能对迟发型和早发型哮喘有不同的作用。然而，很少有人知道发病年龄的表型和空气污染之间的关联。在这项以人群为基础的研究中，我们旨在确定哮喘严重程度和空气污染引发哮喘发病的年龄之间的关系。
方法：在2004，我们从台湾南部地区816个小学生和中学生父母中随机筛选出94个父母进行了呼吸健康的横断面问卷调查。参与者有典型的哮喘症状。我们用克立格法评估在哮喘严重性调查的前一年个体暴露于环境空气污染的情况。有序逻辑回归被用来确定暴露在污染空气和哮喘严重程度之间的关系。哮喘发作12年作为一个分界来定义早发型或迟发型哮喘。
结果：这项研究调查了35，682名参与者。23,551名参与者的数据令人满意,响应率为66%。20,508名参与者的年龄在26-50岁之间，703份问卷调查确定了患哮喘的患者纳入分析。使用PM10的中位数（66μg/m（3））作为分界，那些暴露在高PM10的患者，其严重程度评分仅在哮喘发病超过12年的人群中可能更高（OR = 1.74；95% CI，1.13 - 2.70）。
结论：在成年后，暴露于PM10对迟发型哮喘比早发型哮喘有更大的影响，需要对PM10的空气污染更加重视。
（杨冬 审校）
BMC Pulm Med. 2016 Apr 19;16(1):54. doi: 10.1186/s12890-016-0218-0.
Age of asthma onset and vulnerability to ambient air pollution: an observational population-based study of adults from Southern Taiwan.
Wu TJ1,2, Wu CF1, Chen BY3, Lee YL4, Guo YL5,6,7.
Author information
Abstract
BACKGROUND:Late-onset asthma (onset > 12 years) is pathologically distinct from early-onset asthma. The mechanism of air pollution is not a classic allergic inflammation and could have differential effect on late-onset and early-onset asthma. However, there is little known about the association of onset-age phenotype and air pollution. In this population-based study, we aimed to determine the association of asthma severity outcomes and air pollution regarding age at onset of asthma.
METHODS:In 2004, we conducted a cross-sectional questionnaire survey about respiratory health among schoolchildren's parents randomly selected from 94 of 816 elementary and middle schools in southern Taiwan. Participants ever having typical asthma symptoms were enrolled. We used kriging method to estimate individual exposure to ambient air pollution in the preceding year before the year of asthma severity survey. Ordered logistic regression was used to determine the association of exposure and asthma severity scores. Age at asthma onset of 12 years was used as a cut-off to define early- or late-onset asthma.
RESULTS:The study surveyed 35,682 participants. Data from 23,551 participants remained satisfactory with a response rate of 66 %. Among 20,508 participants aged 26-50 years, 703 questionnaire-determined asthmatics were identified and included for analysis. Using the median of PM10 (66 μg/m(3)) as a cut-off, those exposed to higher PM10 were more likely to have higher severity scores (OR = 1.74; 95 % CI, 1.13 - 2.70) only for asthmatics with asthma onset at > 12 years.
CONCLUSIONS:In adulthood, exposure to PM10 has a greater effect on late-onset asthma than early-onset asthma and deserves greater attention among ambient air pollutants.
KEYWORDS:Adult asthma; Air pollution; Particulate matter; Phenotype
BMC Pulm Med. 2016 Apr 19;16(1):54. doi: 10.1186/s12890-016-0218-0.
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早期食用花生后对避免花生过敏的影响
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