韩国学龄儿童特应性皮炎的危险因素：2010年儿童哮喘和过敏的国际研究
2016/05/31
摘要
背景和目的：我们旨在研究2010年韩国学龄儿童特应性皮炎(AD)的危险因素
方法：一个全国性的、横向的研究在随机抽取的6-7岁的儿童和12-13岁青少年中间进行。通过韩国版本的哮喘和过敏儿童的国际研究(ISAAC)问卷调查获取数据，并进行皮刺实验。应用逻辑回归分析法对诊断为AD的儿童进行危险因素分析。
结果：我们招募了6-7岁的4,003名儿童（M/F = 2,021/1,982）和12-13岁的4,112名儿童（M/F = 2,029/2,083）。6-7岁儿童中，AD诊断的终生患病率为35.6%（N = 1,424；在12-13岁的年龄组，AD诊断的终生患病率为24.2%（N = 981）。6-7岁儿童的单因素逻辑回归分析发现，可能的风险因素是过敏体质、父母过敏性疾病史、在婴儿期使用抗生素、幼年时期搬进过新建房子、在屋内存在可见霉菌、在12个月内改建房子。数据调整后的统计分析仍然具有显著性。然而，在婴儿期使用抗生素和12个月内改建房子没有统计的显著性相关。相反地，在青少年组的多因素逻辑回归分析表明：女性、过敏体质、父母具有过敏疾病史、屋内有可见霉菌，以及婴儿期搬入新建的房子里都和AD相关。其它因素与AD没有明显相关。
结论：在韩国学生中，诸如过敏体质、父母有过敏性疾病史、婴儿期搬入新建的房子、屋内有可见霉菌等与AD相关。
（杨冬 审校）
Asian Pac J Allergy Immunol. 2016 Mar;34(1):65-72. doi: 10.12932/AP0621.34.1.2016.
Risk factors of atopic dermatitis in Korean schoolchildren: 2010 international study of asthma and allergies in childhood.
Park YM1, Lee SY, Kim WK, Han MY, Kim J, Chae Y, Hahm MI, Lee KJ, Kwon HJ, Park KS, Park JS, Ahn K.
Author information
Abstract
BACKGROUND & OBJECTIVE:We aimed to analyse the risk factors of atopic dermatitis (AD) in Korean schoolchildren in 2010.
METHODS:A nationwide, cross-sectional study was conducted in children aged 6-7 years and adolescents aged 12-13 years who were randomly selected. Information was obtained through a Korean version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC), and skin prick tests were performed. AD-diagnosed children were selected for risk factor analysis by using logistic regression.
RESULTS:We enrolled 4,003 children (M/F=2,021/ 1,982) in aged 6-7 years and 4,112 children (M/F=2,029/2,083) in 12-13 years. In children aged 6-7 years, the lifetime prevalence of AD diagnosis was 35.6% (N=1,424). On the other hand, in the 12 to 13 year age group, the lifetime prevalence of AD diagnosis was 24.2% (N=981). In the univariate logistic regression analysis in 6-7 year-old children, possible risk factors were atopy, a parental history of allergic disease, the use of antibiotics during infancy, a history of having moved into a newly built house during infancy, the presence of visible mould in the house, and remodelling of house within 12 months. The statistical significance persisted after adjustment. However, antibiotic use during infancy and remodelling within 12 months showed no statistical significance as a risk factor for AD. In contrast, multivariate logistic regression analysis in adolescents demonstrated that female sex, atopy, a parental history of allergic diseases, the presence of visible mould in the house, and a history of having moved into a newly built house during infancy was associated with AD. There was no significant association between AD and other risk factors.
CONCLUSION:In Korean schoolchildren, risk factors such as atopy, the presence of parental allergic diseases, moving into a newly built house during infancy and visible mould in the house were associated with AD.
Asian Pac J Allergy Immunol. 2016 Mar;34(1):65-72. doi: 10.12932/AP0621.34.1.2016.
上一篇：
在瑞士的成年人中，鼻炎与哮喘和早期生活因素有关，但不是二手烟或肥胖
下一篇：
母婴危险因素对儿童哮喘的相对重要性及叠加效应
