哮喘联盟

   摘要
   目的：本研究旨在探索对胃食管反流病(GERD)相关咳嗽进行腹腔镜下胃底折术的疗效和安全性。
   方法：本研究对2008年6月至2013年6月期间在第二炮兵总医院胃食管反流科接受腹腔镜下胃底折术的70例患有GERD相关咳嗽的患者进行回顾性分析。通过问卷的形式将术前和术后的GERD相关症状（反流、烧心、咳嗽、咳痰、异物感和声音嘶哑）进行比较，并计算症状缓解率（术前症状评分－术后症状评分）/术前症状评分×100%)。该研究还对患者的并发症发病率和满意度进行了调查。
   结果：研究显示患者接受抗反流腹腔镜下胃底折术后，反流、烧心、咳嗽、咳痰、异物感和声音嘶哑等GERD相关症状的评分均显著降低（均P<0.01），相关的症状缓解率分别为(79.4±23.2)%、(82.0±21.5)%、(72.2±28.5)%、(62.6±28.9)%、(76.1±31.5)%和(70.8±39.3)%。没有严重并发症和死亡发生。5例患者(7.1%)出现了腹腔积气相关的胸部或颈部皮下气肿，17例患者(24.3% )有不同程度的早期或者晚期的吞咽困难，6例患者(8.6%)出现肠道排气增多，还有2例患者出现了术后胀气。所有的并发症都可在接受适当治疗后被治愈。在所有的患者中，16例患者(15.7%)感到非常满意，37例患者(52.9%)感到满意，11例患者(15.7%)认为可以接受，4例患者(5.7%)感到不满意，还有2例患者对手术感到非常不满意。
   结论：腹腔镜下胃底折术治疗GERD相关咳嗽是安全有效的，并且具有相当高的患者满意度。
 

（苏欣 审校）
Zhonghua Wei Chang Wai Ke Za Zhi. 2015 Dec 25;18(12):1244-7.

Laparoscopic fundoplication for gastroesophageal reflux disease-related cough: a report of 70 cases.
 

[Article in Chinese]
Hu Z1, Wu J, Liang W, Yan C, Wang Z.
 

Abstract
OBJECTIVE:To investigate the efficacy and safety of laparoscopic fundoplication for gastroesophageal reflux disease (GERD)-related cough.
METHODS:Retrospective review of 70 patients with GERD-related cough who received laparoscopic fundoplication in GERD Department of The Second Artillery General Hospital during June 2008 to June 2013 was carried out. GERD-related symptoms (reflux, heartburn, cough, expectoration, globus sensation and hoarseness) before and after surgery were compared through questionnaire, and the symptom remission rate (preoperative symptom score - postoperative symptom score)/preoperative symptom score×100%) was calculated. Complication morbidity and satisfaction degree of patients were investigated.
RESULTS:The GERD-related symptom scores of regurgitation, heartburn, cough, expectoration, globus sensation and hoarseness all significantly decreased (all P<0.01) after the anti-reflux laparoscopic fundoplication, with the corresponding symptom remission rates as (79.4±23.2)%, (82.0±21.5)%, (72.2±28.5)%, (62.6±28.9)%, (76.1±31.5)% and (70.8±39.3)% respectively. No major complication and death occurred. Five cases (7.1%) had pneumoperitoneum-related chest or neck subcutaneous emphysema, 17 cases (24.3% ) had various degree of early and late dysphagia, 6 cases (8.6%) had increased flatus and 2 cases had bloating after surgery. All the complications could be cured by appropriate treatment. Among all the patients, 16 cases (15.7%) felt very satisfied, 37 cases (52.9%) felt satisfied, 11 cases (15.7%) felt acceptable, 4 cases (5.7%) felt unsatisfied and 2 cases felt very unsatisfied with the surgery.
CONCLUSION:Laparoscopic fundoplication is safe and effective for GERD-related cough, with quite high satisfaction degree form patients.
 

Zhonghua Wei Chang Wai Ke Za Zhi. 2015 Dec 25;18(12):1244-7.