哮喘联盟

   摘要
   目的:第一次分娩前的吸烟增加了乳腺癌风险，但是其生物学机制仍是未知的，并且可能与乳腺X线密度(MD)有关，这是乳腺癌风险最强的生物标记之一。 我们旨在检测主动吸烟和被动吸烟是否与MD相关。
   方法:来自丹麦饮食、癌症与健康队列(1993-1997)的，在哥本哈根(1993-2001)进行乳腺X线筛查的5,356名女性 (4,489名绝经后) ，我们采用其进入队列后第一次筛查的MD (混合/密集或脂肪) 评价结果。主动吸烟 (状态，持续时间，和强度) 、被动吸烟人群及其他乳腺癌风险因素在队列的基线水平通过问卷评估 (1993-1997)。 Logistic回归分析用于估计吸烟与MD之间相关性 (优势比, 95 % 置信区间)，校正混杂因素。
   结果:2,026(56.5 %)名女性具有混合/密集MD， 2,214 名(41.4 %)为现吸烟者 ，1,175 名(21.9 %)为前吸烟者。与非吸烟者相比，现吸烟者具有明显低的混合/密集 MD几率(0.86, 0.75-0.99)，而前吸烟者与MD无关。吸烟与MD的负相关关系在16岁前吸第一支烟(0.79, 0.64-0.96)，吸≥15只/天(0.83, 0.71-0.98)，大于等于5包/年(0.62, 0.43-0.89)，烟龄大于30年(0.86, 0.75-0.99)，以及在第一次分娩前吸烟≥11年(0.70, 0.51-0.96)的女性中最强。吸烟与MD的相关性在戒烟后减弱，而戒烟＞20年的女性与现吸烟者相比有较高几率的混合/密集乳腺 (1.37, 1.01-1.67)。被动吸烟与MD无关。
   结论:我们发现主动吸烟与MD呈负相关关系。

 

（苏欣 审校）
Cancer Causes Control. 2015 Dec 8. [Epub ahead of print]

 

Cigarette smoking and mammographic density in the Danish Diet, Cancer and Health cohort.
 

Jacobsen KK1,2, Lynge E3, Vejborg I4, Tjønneland A5, von Euler-Chelpin M3, Andersen ZJ3.

 

Abstract
PURPOSE:Smoking before first childbirth increases breast cancer risk, but the biological mechanism remains unknown and may involve mammographic density (MD), one of the strongest biomarkers of breast cancer risk. We aimed to examine whether active smoking and passive smoking were associated with MD.
METHODS:For the 5,356 women (4,489 postmenopausal) from the Danish Diet, Cancer and Health cohort (1993-1997) who attended mammographic screening in Copenhagen (1993-2001), we used MD (mixed/dense or fatty) assessed at the first screening after cohort entry. Active smoking (status, duration, and intensity) and passive smoking were assessed at cohort baseline (1993-1997) via questionnaire, together with other breast cancer risk factors. Logistic regression was used to estimate associations (odds ratios, 95 % confidence intervals) between smoking and MD, adjusting for confounders.
RESULTS:Two thousand and twenty-six (56.5 %) women had mixed/dense MD, 2,214 (41.4 %) were current, and 1,175 (21.9 %) former smokers. Current smokers had significantly lower odds (0.86, 0.75-0.99) of having mixed/dense MD compared to never smokers, while former smoking was not associated with MD. Inverse association between smoking and MD was strongest in women who initiated smoking before age of 16 years (0.79, 0.64-0.96), smoked ≥15 cigarettes/day (0.83, 0.71-0.98), smoked ≥5 pack-years (0.62, 0.43-0.89), smoked >30 years (0.86, 0.75-0.99), and smoked ≥11 years before first childbirth (0.70, 0.51-0.96). Association between smoking and MD diminished after smoking cessation, with increased odds of having mixed/dense breasts in women who quit smoking >20 years ago as compared to current smokers (1.37, 1.01-1.67). There was no association between passive smoking and MD.
CONCLUSIONS:We found an inverse association between active smoking and MD.
 

Cancer Causes Control. 2015 Dec 8. [Epub ahead of print]