哮喘联盟

   摘要
   背景：儿童期的过敏性疾病对儿童的生活质量存在一定影响，同时对其父母的生活质量也造成影响。本研究旨在评估使用哮喘药物治疗的儿童多种过敏性疾病并存的情况。另外，本研究假设伴有多种过敏性疾病并存的儿童，其哮喘更严重。
   方法：本研究为横断面研究，纳入的703名儿童（4-12岁）来源于PACMAN队列研究。所有儿童均常规使用哮喘药物。根据父母所述儿童的过敏情况（花粉症、湿疹、食物过敏或以上兼有）分为9个亚组。通过比较各组儿童特征（年龄、性别、哮喘家族史）、过去一年哮喘急性发作（口服糖皮质激素的使用、哮喘相关急诊就诊情况）、哮喘控制、呼出气一氧化氮(FeNO)及抗组胺药物的使用情况，以评估各亚组的临床特征是否不同。
   结果：本研究中，79.0 %的父母声称他们的孩子至少患有一种特应性疾病（花粉症、食物过敏及湿疹），25.6 %的父母声称他们的孩子以上三种特应性疾病均有。患有一种以上的特应性疾病与口服糖皮质激素使用(OR = 3.3, 95 % CI: 1.6 - 6.6)、过去一年的急诊就诊次数(OR = 2.3, 95 % CI : 1.2 - 4.6)、短期哮喘控制不佳(OR = 1.9, 95 % CI : 1.3 - 2.8)的风险增加有关。
   结论：使用哮喘药物治疗的儿童通常伴有其他过敏性疾病。父母所述的过敏疾病与儿童更严重哮喘（合并更多哮喘并发症和急性发作次数更多）风险升高相关。
 

（杨冬 审校）
BMC Pediatr. 2015 Nov 6;15(1):172. doi: 10.1186/s12887-015-0481-x.
 

Characteristics and severity of asthma in children with and without atopic conditions: a cross-sectional study.
 

Arabkhazaeli A1, Vijverberg SJ2, van Erp FC3, Raaijmakers JA4, van der Ent CK5, Maitland van der Zee AH6.
 

Abstract
BACKGROUND:Childhood allergic diseases have a major impact on a child's quality of life, as well as that of their parents. We studied the coexistence of reported allergies in children who use asthma medication. Additionally, we tested the hypothesis that asthma severity is greater among children with certain combinations of co-morbid allergic conditions.
METHODS:For this cross-sectional study, 703 children (ages 4 to 12 years) from the PACMAN cohort study were selected. All of the children were regular users of asthma medication. The study population was divided into nine subgroups according to parental-reported allergies of the child (hay fever, eczema, food allergy or combinations of these). In order to assess whether these subgroups differed clinically, the groups were compared for child characteristics (age, gender, family history of asthma), asthma exacerbations in the past year (oral corticosteroids (OCS) use; asthma-related emergency department (ED) visits), asthma control, fractional exhaled nitric oxide level (FeNO), and antihistaminic usage.
RESULTS:In our study, 79.0 % of the parents reported that their child suffered from at least one atopic condition (hay fever, food allergy and eczema), and one quarter of the parents (25.6 %) reported that their child suffered from all three atopic conditions. Having more than one atopic condition was associated with an increased risk of OCS use (OR = 3.3, 95 % CI = 1.6 - 6.6), ED visits (OR = 2.3, 95 % CI = 1.2 - 4.6) in the past year and inadequate short term asthma control (OR = 1.9, 95 % CI = 1.3 - 2.8).
CONCLUSIONS:Children who use asthma medication often also have other allergic conditions. Parental reported allergies were associated with a higher risk of more severe asthma (more asthma complaints and more asthma exacerbations).
 

BMC Pediatr. 2015 Nov 6;15(1):172. doi: 10.1186/s12887-015-0481-x.