哮喘联盟

   摘要
   背景：硫酸镁(MgSO4)用于治疗重度哮喘急性发作，耐受性好，价格便宜，且疗效显著。本研究旨在通过调查治疗哮喘患者的医生来评估其对硫酸镁的认识及硫酸镁的临床应用情况。
   方法：通过E-mail向土耳其国家过敏与临床免疫学会会员发送自填式调查问卷，并分发至年会的参与者。
   结果：共收到456名医生（平均年龄36.53±9.11岁）的回复，42.3%的医生在临床中使用MgSO4治疗哮喘急性发作，48.7%的医生赞成MgSO4应纳入指南推荐。MgSO4最主要的适应症是使用支气管扩张剂或全身性糖皮质激素仍然难以控制的患者 (67.7%)。使用MgSO4最主要的两个原因是可以有效缩短住院时间(94.7%)和避免疾病进展入住ICU (80.3%)。医生主要使用MgSO4治疗重度或致命性急性哮喘发作。39%的医生认为MgSO4对出院患者无效，其中，29%认为MgSO4副作用小。不用MgSO4最常见的原因是价格便宜(36.5%)。多因素分析显示，专业背景(OR=3.20，p<0.001)、每月的哮喘门诊患者数量(OR=1.82, p=0.007) 以及最近从医学院毕业(晚于1991年) (OR=0.23, p<0.001)与MgSO4的使用有关，。
   结论：即使MgSO4治疗急性重度哮喘的疗效众所周知，但临床中仅有一半的医生使用MgSO4治疗哮喘。因此，有必要对医生进行MgSO4相关知识教育，进一步推动、促进MgSO4在临床中的应用。
 

（杨冬 审校）
J Asthma. 2015 Oct 7:1-25. [Epub ahead of print]


 

Survey of physicians' attitudes towards the use of magnesium sulfate for acute asthma exacerbations in Turkey.
 

Baççıoğlu A1, Bakırtaş A2, Öner Erkekol F3, Kalaycı Ö4, Bavbek S5.
 

Abstract
BACKGROUND:Magnesium sulfate (MgSO4) is considered to be a well tolerated, inexpensive, and effective medication for severe asthma exacerbations. We surveyed physicians who treat patients with asthma to evaluate the current knowledge and usage of MgSO4.
METHODS:A self-administered questionnaire was e-mailed to members of the Turkish National Society of Allergy and Clinical Immunology and was distributed to participants of its annual congress.
RESULTS:Of the 456 respondents (mean age: 36.53±9.11yrs), 42.3% reported to use MgSO4 in asthma exacerbations in their practice, and 48.7% agreed that MgSO4 was included in asthma guidelines. The best known indication was that it was useful only in patients refractory to bronchodilators and systemic corticosteroids (67.7%). The two most common reasons to use MgSO4 were to shorten hospital stay (94.7%), and prevent admission to intensive care unit (80.3%). The respondents mostly used MgSO4 in the treatment of severe or life-threatening exacerbations. Thirty-nine percent believed that MgSO4 had no effect on discharge period, and 29% of them marked minor side effects. The most common reason for not using MgSO4 was inexperience (36.5%). Having an academic affiliation (OR=3.20, p<0.001), the number of asthmatic outpatients seen per month (OR=1.82, p=0.007), and more recent graduation from medical school (≤ 1991)(OR=0.23, p<0.001) were associated with the use of MgSO4 in the multivariate analysis.
CONCLUSION:Even though the effect of MgSO4 in acute severe asthma is well known, only half of the physicians dealing with asthma patients have used it in their practice. Education and encouragement in this regard are necessary.
 

J Asthma. 2015 Oct 7:1-25. [Epub ahead of print]