哮喘联盟

   摘要
   背景：一项横断面回顾性研究表明过敏性疾病与帕金森氏症之间存在联系。然而哮喘和帕金森氏症之间的时态关联尚不得而知。
   方法：从台湾全民健康保险研究资料库中选取41820例，自1998年至2008年间诊断为哮喘且年龄≧45岁的患者做年龄和性别匹配的对照研究，观察至2011年底。对随访期间患上帕金森氏症的患者进行鉴定。以因哮喘加重而入院的次数（每年次）为指标研究了患者哮喘的严重度，及继发帕金森氏症的风险。
   结果：校正了人口统计数据、卫生系统应用、内科并发症以及药物使用后发现，哮喘患者患帕金森氏症的风险增加（危害比[HR]：3.10，95％置信区间[CI]：2.20-4.36）。剔除了开始第一年（HR：2.90，95％CI：2.04-4.13）和开始前三年（HR：2.46，95％CI：1.64-3.69）的观测值后，药敏试验也取得了一致结论。随访期间住院次数较频繁的哮喘患者继发帕金森氏症的风险更大(> 2: HR: 16.42, 95% CI: 5.88-45.91; 1-2: 12.69, 95% CI: 5.03-31.71; 0-1: HR: 2.92, 95% CI: 1.91-4.49)。
   结论：哮喘患者在日后患帕金森氏症的风险增加，还发现哮喘严重程度与继发帕金森氏症风险之间的剂量依赖关系。
 

（苏欣 审校）
Allergy. 2015 Aug 27. doi: 10.1111/all.12758. [Epub ahead of print]


 

Risk of developing Parkinson's disease among patients with asthma: a nationwide longitudinal study.
 

Cheng CM1, Wu YH2,3, Tsai SJ1,4, Bai YM1,4, Hsu JW1,4, Huang KL1,4, Su TP1,4, Li CT1,4, Tsai CF1,4, Yang AC1,4, Lin WC1,4, Pan TL5,6,7, Chang WH1, Chen TJ8,9, Chen MH1,4.
 

Abstract
BACKGROUND:A cross-sectional retrospective study suggested a link between allergic diseases and Parkinson's disease. However, the temporal association between asthma and Parkinson's disease remains unknown.
METHODS:From the Taiwan National Health Insurance Research Database, 10,455 patients who were diagnosed with asthma between 1998 and 2008 and aged ≧ 45 years and 41,820 age- and sex-matched controls were selected for our study and observed until the end of 2011. Those who developed Parkinson's disease during the follow-up period were identified. We also examined the asthma severity, as indicated by the frequency of admission (times per year) for asthma exacerbation, and the risk of subsequent Parkinson's disease.
RESULTS:Patients with asthma had an increased risk of developing Parkinson's disease (hazard ratio [HR]: 3.10, 95% confidence interval [CI]: 2.20-4.36) after we adjusted for demographic data, health system use, medical comorbidities, and medication use. Sensitivity tests yielded consistent findings after we excluded observations on the first year (HR: 2.90, 95% CI: 2.04-4.13) and first 3 years (HR: 2.46, 95% CI: 1.64-3.69). Patients with asthma who had more frequent admissions (times per year) during the follow-up period exhibited a greater risk of subsequent Parkinson's disease (> 2: HR: 16.42, 95% CI: 5.88-45.91; 1-2: 12.69, 95% CI: 5.03-31.71; 0-1: HR: 2.92, 95% CI: 1.91-4.49).
CONCLUSION:Patients with asthma had an elevated risk of developing Parkinson's disease later in life, and we observed a dose-dependent relationship between greater asthma severity and a higher risk of subsequent Parkinson's disease.
 

Allergy. 2015 Aug 27. doi: 10.1111/all.12758. [Epub ahead of print]