哮喘联盟

   摘要
   目的:我们在全地区范围内评估了炎症性肠病 (IBD)成人患者的哮喘发展风险。
   方法:采用了来自台湾国家健康保险研究数据库的数据以进行回顾性队列研究。年龄为20岁及以上，在2000和2005年间新近确诊IBD的患者，随机地以频数匹配（基于性别，年龄，和年份）4倍人数来自普通人群未患IBD的纳入者。两个队列均随访至2011年末以研究哮喘的发病率。Cox比例风险回归分析被用来来衡量IBD队列与非IBD队列的哮喘风险比（HR）。
   结果:IBD和非IBD队列分别包含有5260名IBD患者和21,040名参与者。调整协变量后，IBD队列显示出1.50倍的哮喘风险增加(HR 1.50, [95% 置信区间{CI}, 1.32-1.71])。根据IBD队列的两个主要形式进一步分析表明，与非IBD队列相比，调整后的哮喘HR在溃疡性结肠炎患者中为 1.46 (95% CI, 1.03-2.07)，在克罗恩病患者中为1.50 (95% CI, 1.31-1.72)。
   结论:在调整过合并症后，IBD患者与更高的后续哮喘风险相关。
 

（苏欣 审校）
Allergy Asthma Proc. 2015 Sep;36(5):92-8. doi: 10.2500/aap.2015.36.3869.

 

Association of inflammatory bowel disease with asthma risk: A nationwide cohort study.
 

Peng YH1, Liao WC, Su CH, Chen HJ, Hsia TC, Chu CC, Liu CJ, Kao CH.
 

Abstract
OBJECTIVE:We evaluated the risk of asthma development in adult patients with inflammatory bowel disease (IBD) in a nationwide population.
METHODS:A retrospective cohort study was conducted by using data retrieved from the Taiwan National Health Insurance Research Database. Patients, ages 20 year or older, with newly diagnosed IBD between 2000 and 2005 were identified and randomly frequency-matched (based on sex, age, and index year) with four times the number of enrollees without IBD from the general population. Both cohorts were followed up until the end of 2011 to examine the incidence of asthma. Cox proportional hazard regression analysis was used to measure the hazard ratios (HR) of asthma in the IBD cohort compared with that in the non-IBD cohort.
RESULTS:The IBD and non-IBD cohorts comprised 5260 patients with IBD and 21,040 participants, respectively. After adjustment for covariates, the IBD cohort exhibited a 1.50-fold increased risk for asthma (HR 1.50, [95% confidence interval {CI}, 1.32-1.71]). Further analysis according to the two major forms of IBD revealed that the adjusted HR of asthma was 1.46 (95% CI, 1.03-2.07) and 1.50 (95% CI, 1.31-1.72) in patients with ulcerative colitis and Crohn's disease, respectively, compared with the non-IBD cohort.
CONCLUSION:After adjustment for comorbidities, patients with IBD were associated with a higher subsequent risk of asthma.
 

Allergy Asthma Proc. 2015 Sep;36(5):92-8. doi: 10.2500/aap.2015.36.3869.