哮喘联盟

   摘要
   背景：文献报道成年哮喘患者的高血压发病率增加。然而，并没有证据证实高血压和哮喘严重程度存在相互作用。
   目的：本研究的目的在于探讨高血压的伴随诊断是否影响成人哮喘患者哮喘严重程度的标志物。
   方法：共117922例18岁及以上的哮喘患者源自Kaiser Permanente数据库。分别对短效β受体激动剂使用大于6(SABA > 6)、急诊就诊或住院治疗史（EDHO）和糖皮质激素制剂（CCS）使用的病例进行病例对照研究。对照组进行年龄和性别匹配。单变量和多变量条件逻辑回归被用来评估SABA > 6、 EDHO和 CCS与高血压相关性的比值比（OR）和95%可信区间（Cl）。
   结果：校正潜在的混杂因素后，高血压与增加的SABA > 6 (OR 1.19, CI 1.13-1.26, n = 15,855 病例 和76,060 对照)、EDHO (OR 1.11, CI 1.03-1.19, n = 9,307病例和46,535 对照)和 CCS (OR 1.15, CI 1.10-1.19, n = 53,690病例和53,690对照) 相关。
   结论：为合并高血压的哮喘受试者哮喘发病率增加提供证据支持。
 

（杨冬 审校）
JAllergyClinImmunolPract. 2015Sep2.pii:S2213-2198(15)00390-6.doi:10.1016/j.jaip.2015.07.009. [Epub ahead of print]

 

Hypertension and Asthma: A Comorbid Relationship.
 

Christiansen SC1, Schatz M2, Yang SJ3, Ngor E3, Chen W3, Zuraw BL4.
 

Abstract
BACKGROUND:An increased prevalence of hypertension has been described in adult asthmatic patients. However, there is no information regarding the interaction of hypertension as a comorbidity with asthma severity.
OBJECTIVE:The objective of this study was to investigate whether a concomitant diagnosis of hypertension had any impact on markers of asthma severity in adult asthmatic patients.
METHODS:A total of 117,922 asthmatic subjects 18 years or older were identified in the Kaiser Permanente database. Case-control studies were conducted with cases defined by short-acting β-agonist canister dispensing greater than 6 (SABA > 6), history of emergency department visits or hospitalizations (EDHO), and corticosteroid dispensings (CCS), respectively. Controls were matched by age and sex. Univariate and multivariate conditional logistic regression was applied to estimate the odds ratios (OR) and 95% confidence intervals (CI) for SABA > 6, EDHO, and CCS associated with the diagnosis of hypertension.
RESULTS:Hypertension was associated with an increased odds of SABA > 6 (OR 1.19, CI 1.13-1.26, n = 15,855 cases and 76,060 controls), EDHO (OR 1.11, CI 1.03-1.19, n = 9,307 cases and 46,535 controls), and CCS (OR 1.15, CI 1.10-1.19, n = 53,690 cases and 53,690 controls) after adjusting for potential confounders.
CONCLUSIONS:Asthmatic subjects with comorbid hypertension display evidence of enhanced of asthma morbidity.
 

JAllergyClinImmunolPract. 2015Sep2.pii:S2213-2198(15)00390-6.doi:10.1016/j.jaip.2015.07.009. [Epub ahead of print]