哮喘和前列腺癌风险：一项基于台湾人群的病例队列研究
2015/11/20
摘要
西方国家的几项流行病学研究已经探索了哮喘和前列腺癌风险之间的联系，但是结果仍然是不确定的。我们通过一项大型全国性的基于人群的病例队列研究来研究两者之间的联系。我们使用了1997年到2008年间台湾国民健康保险调查的数据库，收集了12,372例男性的数据，其中包括了4124例哮喘患者和8248例年龄、居住地和保险费用相匹配的对照者，这些对照者从未被诊断过哮喘。竞争性风险-校正Cox比例风险回归被用来计算危害比(HRs)和95%置信区间(CI)从而判定前列腺癌与哮喘之间的相关性。在平均随访时间5.05年中(标准差, 2.10)，有74例前列腺癌患者。哮喘患者的前列腺癌发病率为163.0/100,000人-年 (95% CI: 113.0-228.0)。经过对年龄、居住地、保险花费、高甘油三酯血症、高血压、糖尿病、慢性阻塞性肺病、住院时间以及死亡率进行校正后，哮喘与前列腺癌显著相关(HR: 2.36; 95% CI: 1.22-4.57; P = 0.011)。亚组分析发现，哮喘患者中前列腺癌的独立风险因子为年龄(HR: 1.09; 95% CI: 1.05-1.21; P < 0.001)和高血压(HR: 2.75; 95% CI: 1.24-7.80; P = 0.047)。 我们研究的结果提示哮喘患者患前列腺癌的风险增加。
（杨冬 审校）
Medicine (Baltimore). 2015 Sep;94(36):e1371. doi: 10.1097/MD.0000000000001371.
Asthma and Risk of Prostate Cancer: A Population-Based Case-Cohort Study in Taiwan.
Su YL1, Chou CL, Rau KM, Lee CT.
Abstract
Several epidemiologic studies in Western countries have examined the association between asthma and prostate cancer risk, but the results have been inconclusive. We investigated this association in a large, nationwide, population-based case-cohort study. Using the Taiwan National Health Insurance Research Database from 1997 to 2008, we collected data from 12,372 men, including 4124 with asthma and 8248 age-, residence-, and insurance premium-matched control subjects, who were never diagnosed with asthma. Competing risk-adjusted Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and 95% confidence interval (CI) for determining the association between prostate cancer and asthma. During a mean follow-up of 5.05 years (standard deviation, 2.10), there were 74 cases of prostate cancer. The incidence of prostate cancer was 163.0/100,000 person-years (95% CI: 113.0-228.0) in the asthma patients. Asthma was significantly associated with prostate cancer (HR: 2.36; 95% CI: 1.22-4.57; P = 0.011) after adjusting for age, residential area, insurance premium, hypertriglyceridemia, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, duration of hospitalization, and mortality. In the subgroup analysis, independent risk factors for prostate cancer among men with asthma were age (HR: 1.09; 95% CI: 1.05-1.21; P < 0.001) and hypertension (HR: 2.75; 95% CI: 1.24-7.80; P = 0.047). The results of our study suggest that men with asthma have an increased risk of prostate cancer.
Medicine (Baltimore). 2015 Sep;94(36):e1371. doi: 10.1097/MD.0000000000001371.
