哮喘联盟

   摘要
   老年人口正在增加，而哮喘的严重程度随着年龄增加而增加。我们确定了老年哮喘患者中哮喘控制、急性发作的预测因子和影响哮喘特定生存质量(A-QOL)的因素。这是一项前瞻性、多中心为期6个月的现实生活研究，采用了基于全球哮喘倡议 (GINA)指南的分级药物治疗。总共招募了296例来自韩国5所大学研究中心的大于等于60岁的哮喘患者。哮喘控制改善组定义为能保持良好的哮喘控制或改善疾病者，哮喘控制未改善组定义为前者以外的患者。较少的并发症治疗的药物数量（改善组2.8 ± 3.3 vs.对照组 4.5 ± 4.4 ) 和更高的生理功能 (PF) 值（改善组89.8 ± 14.2 vs.对照组 82.0 ± 16.4）是哮喘控制改善组的显著预测因子 (分别为OR = 0.863, P = 0.004 和OR = 1.028, P = 0.018 )。哮喘控制试验(ACT)基线水平评分≤ 19者是哮喘急性发作的显著预测因子 (OR = 3.938, P = 0.048)。哮喘患病年限 (F = 5.656, P = 0.018)、基线ACT评分(F = 12.237, P = 0.001)和哮喘急性发作(F = 5.565, P = 0.019)是A-QOL变化的决定因素。并发症药物数量和PF值决定的体力状态可能是评估老年哮喘患者哮喘控制情况的重要参数。
 

（杨冬 审校）
J Korean Med Sci. 2015 Aug;30(8):1042-7. doi: 10.3346/jkms.2015.30.8.1042. Epub 2015 Jul 15.

 

Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients.
 

Ban GY1, Ye YM1, Lee Y2, Kim JE3, Nam YH4, Lee SK4, Kim JH5, Jung KS5, Kim SH6, Park HS1; Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group.
 

Abstract
The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improvedasthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 ± 3.3 in the improved vs. 4.5 ± 4.4 in the control) and higher physical functioning (PF) scale (89.8 ± 14.2 in the improved vs. 82.0 ± 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of ≤ 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessingasthma control in elderly asthmatic patients.
 

J Korean Med Sci. 2015 Aug;30(8):1042-7. doi: 10.3346/jkms.2015.30.8.1042. Epub 2015 Jul 15.