哮喘联盟

   摘要
   目的:确定儿童哮喘相关的因素.
   方法:本病例对照研究在卡拉奇Lyari 综合医院的儿科门诊进行，研究从2010年5月到10月期间进行。 以1～15岁门诊就医的儿童为病例组， 对照组为病例组近亲 (兄弟姐妹或堂、表兄弟姐妹)同时没有相应疾病的症状表现。 收集的数据进行统计并使用SPSS 10软件分析。
   结果:在总共的346例中, 分成两组，每组173例(50%)。 根据单变量分析，以下因素与儿童哮喘相关：家里至少一人吸烟(优势比OR: 3.6; 95% 置信区间: 2.3-5.8),居住在Kacha 的居民(优势比OR: 16.2; 95% 置信区间: 3.8-69.5),在无窗房间中生活 (优势比OR: 9.3; 95% 置信区间: 2.1-40.9) 和住宅无充足阳光者 (优势比OR: 1.6; 95%  置信区间: 1.2-2.4)。使用多变量模型，调整年龄、性别和儿童断奶史， 儿童哮喘的独立危险因素包括：哮喘家族史 (优势比OR: 5.9; 95% 置信区间: 3.1-11.6), 家中至少有一名吸烟者 (优势比OR: 4.1; 95%  置信区间: 2.3-7.2), 生活在无窗房间(优势比OR: 5.5; 95%  置信区间: 1.15-26.3) 和生活在无充足阳光的房间(优势比OR: 2.2; 95%置信区间: 1.13-4.31) 。
   结论:儿童患哮喘的主要高危因素包括：有哮喘家族史, 生活在吸烟家庭（≥1人吸烟），家里没有窗以及房间阳光不足。


 

（苏欣 审校）
 J Pak Med Assoc. 2015 Jun;65(6):647-50.

 

Risk factors of childhood asthma in children attending Lyari General Hospital.
 

Kamran A1, Hanif S1, Murtaza G1.

Abstract
OBJECTIVE:To determine the factors associated with asthma in children.
METHODS:The case-control study was conducted in the paediatrics clinic of Lyari General Hospital, Karachi, from May to October 2010. Children 1-15 years of age attending the clinic represented the cases, while the control group had children who were closely related (sibling or cousin) to the cases but did not have the symptoms of disease at the time. Data was collected through a proforma and analysed using SPSS 10.
RESULTS:Of the total 346 subjects, 173(50%) each comprised the two groups. According to univariable analysis the risk factors were presence of at least one smoker (odds ratio: 3.6; 95% confidence interval: 2.3-5.8), resident of kacha house (odds ratio: 16.2; 95% confidence interval: 3.8-69.5),living in room without windows (odds ratio: 9.3; 95% confidence interval: 2.1-40.9) and living in houses without adequate sunlight (odds ratio: 1.6; 95% confidence interval: 1.2-2.4).Using multivariable modelling, family history of asthma (odds ratio: 5.9; 95% confidence interval: 3.1-11.6), presence of at least one smoker at home (odds ratio: 4.1; 95% confidence interval: 2.3-7.2), people living in a room without a window (odds ratio: 5.5; 95% confidence interval: 1.15-26.3) and people living in an area without adequate sunlight (odds ratio: 2.2; 95% confidence interval: 1.13-4.31) were found to be independent risk factors of asthma in children adjusting for age, gender and history of weaning.
CONCLUSIONS:Family history of asthma, children living with at least one smoker at home, room without windows and people living in an area without sunlight were major risk factors of childhood asthma.
 

J Pak Med Assoc. 2015 Jun;65(6):647-50.