哮喘联盟

   摘要
   儿童肥胖和哮喘是重要公共健康问题。肥胖不仅增加哮喘发作风险，还可能导致哮喘严重程度/控制恶化。虽然肥胖与哮喘表现联系的机制尚未能完全阐明，证据提示急性呼吸道感染（ARI）频率增加以及糖皮质激素反应性降低可能有助于解释肥胖如何使哮喘表现恶化。此外，肥胖个体维生素D水平较低，已有证据表明维生素D影响急性呼吸道感染风险及哮喘个体的糖皮质激素反应性。本综述总结了儿童肥胖与哮喘严重程度/控制的关系，讨论了急性呼吸道感染和糖皮质激素反应性在肥胖-哮喘通路中的潜在介导作用。本文也讨论了维生素D的潜在作用，并对近期补充维生素D的随机对照试验做了简要概括。
 

（苏欣 审校）
 Expert Rev Respir Med. 2015 May 6:1-17. [Epub ahead of print]

 

The potential role of vitamin Dinthelinkbetweenobesityand asthmaseverity/control in children.
 

Vo P1, Bair-Merritt M, Camargo CA.
Author information
 

Abstract
Childhood obesity and asthma are major public health problems. Obesity is not only associated with increased risk of incident asthma, but it may worsen asthma severity/control. Although the mechanisms linking obesity with asthma expression have not been completely elucidated, evidence suggests that increased frequency of acute respiratory infection (ARI) and decreased corticosteroid responsiveness may help to explain how obesity worsens asthma expression. In addition, obese individuals have low vitamin D status, and emerging evidence suggests vitamin D affects risk of ARI and corticosteroid responsiveness in individuals with asthma. In this review, we summarize the association between obesity and asthma severity/control in children and discuss ARI and corticosteroid responsiveness as potential mediators in the obesity-asthmapathway. We also discuss the potential role of vitamin D, including a brief summary of recent randomized controlled trials of vitamin D supplementation.
 

Expert Rev Respir Med. 2015 May 6:1-17. [Epub ahead of print]