哮喘联盟

   摘要
   文献报道IL-4R Q576R的多态性可以增加哮喘的易感性，但结果存在争议。因此，研究采用meta分析评估中国汉族人群中IL-4R Q576R多态性与哮喘风险的相关性。通过全面检索电子数据库，获得16项符合要求的评估中国汉族人群中IL-4R Q576R和哮喘相关性的病例对照研究，共纳入2077例哮喘患者和1589例对照人群。分析发现，中国汉族人群中IL-4R Q576R多态性 和哮喘风险存在显著相关性（等位基因模型：比值比OR = 1.481, 95%可信区间 = 1.134-1.935, P = 0.004; 线性模型: OR = 1.542, 95%可信区间 = 1.194-1.990, P = 0.001; 隐性模型: OR = 1.695, 95%CI = 1.170-2.456, P = 0.005, 加性模型: OR = 1.897, 95%可信区间 = 1.299-2.771, P = 0.005）。研究发表的日期和总样本的大小可能是导致研究间存在异质性的原因。根据每个研究的样本量进行亚组分析，这种显著相关性仅存在于小样本的亚组中。总之，我们的meta分析结果提示，中国汉族人群中IL-4R Q576R的多态性与哮喘相关。
 

（杨冬 审校）
Genet Mol Res. 2015 Mar 31;14(1):2900-11. doi: 10.4238/2015.March.31.21.
 

Association of the IL-4R Q576R polymorphism and asthma in the Chinese Han population: A meta-analysis.
 

Huang ZY1, Cheng BJ2, Cai GJ3, Zhang BF4.

Author information
 

Abstract
The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R Q576R polymorphism and asthma in the Chinese Han population were obtained by comprehensive literature search incorporating electronic databases, and included 2077 asthma cases and 1589 controls. Our analysis detected a significant association between the IL-4R Q576R polymorphism and the risk of asthma in the Chinese Han population (Allelic model: OR = 1.481, 95%CI = 1.134-1.935, P = 0.004; Dominant model: OR = 1.542, 95%CI = 1.194-1.990, P = 0.001; Recessive model: OR = 1.695, 95%CI = 1.170-2.456, P = 0.005, Additive model: OR = 1.897, 95%CI = 1.299-2.771, P = 0.005). The year of publication and size of total sample might be sources of between-study heterogeneity. Upon subgroup analysis by size of total sample of each study, the significant association only remained in a subgroup with a small sample size. In summary, our meta-analysis suggested that the IL-4R Q576R polymorphism is associated with asthma in the Chinese Han population.
 

Genet Mol Res. 2015 Mar 31;14(1):2900-11. doi: 10.4238/2015.March.31.21.