哮喘联盟

   摘要
   研究的目的是分析有慢性咳嗽症状的患者中典型和非典型细菌的微生物测试结果。总共研究了年龄从2到94岁的慢性咳嗽门诊病人214名（110名女子，64名男子，40名儿童）。对428个咽拭子进行非典型细菌抗原（肺炎衣原体）（n = 214）和典型病原菌（n = 214）的检测。肺炎支原体抗原利用间接免疫荧光试验进行检测，经典的微生物培养法用于典型细菌检测。55/214（26.0％）慢性咳嗽患者被检出肺炎衣原体抗原（其中有女子31名（28.2％），男子14名（21.9％），儿童10名（25.0％））。观察到30名（27.3％）女子，22名（34.4％）男子，21名（52.5％）儿童的典型病原菌培养呈阳性。在16名（7.5％）患者中同时检出肺炎衣原体和典型病原菌（金黄色葡萄球菌菌株MSSA，酿脓链球菌，或卡他莫拉菌）。调查结果显示，在慢性咳嗽患者中，肺炎衣原体感染虽然比典型病原菌感染少，但也是相当频繁的。此外，慢性咳嗽患者的咽拭子测试肺炎衣原体的效能良好，并提供了诊断感染和实施适当治疗的有效方法。
 

（苏欣 审校）
Adv Exp Med Biol. 2015 Feb 28. [Epub ahead of print]

 

Detection of Chlamydophila Pneumoniae and Typical Bacteria in Patients with Chronic Cough.
 

Jama-Kmiecik A1, Frej-Madrzak M, Gosciniak G, Sarowska J, Choroszy-Krol I.

Author information
 

Abstract
The aim of research was to analyze the results of microbiological tests for typical and atypical bacteria in patients with symptoms of chronic cough. A total of 214 outpatients aged from 2 to 94 years (110 women, 64 men, and 40 children) with chronic cough were studied. Four hundred twenty eight throat swabs were examined for atypical bacteria antigen (Chlamydophila pneumoniae) (n = 214) and typical pathogens (n = 214). Chl. pneumoniae detection was performed using indirect immunofluorescence test. Classical microbiological culture was used for typical bacteria detection. Chl. pneumoniae antigen was detected in 55/214 (26.0 %) patients with chronic cough (in 31 (28.2 %) women, 14 (21.9 %) men, and 10 (25.0 %) children). Positive culture for typical pathogens was observed in 30 (27.3 %) women, 22 (34.4 %) men, and 21 (52.5 %) children. Simultaneous occurrence of Chl. pneumoniae and typical pathogens (Staphylococcus aureus strain MSSA, Streptococcus pyogenes, or Moraxella catarrhalis) was found in 16 (7.5 %) patients. The findings show that in patients with chronic cough Chl. pneumoniae infection, although less than that with typical pathogens, is rather frequent. Further, the performance of test for Chl. pneumoniae in throat swabs from patients with chronic cough is good and provides an efficient way to diagnose the infection and implement appropriate therapy.
 

Adv Exp Med Biol. 2015 Feb 28. [Epub ahead of print]