哮喘联盟

   摘要
   背景：此荟萃分析旨在评估哮喘儿童/青少年和其父母的生活质量（QoL) 的损害程度。
   方法：系统检索四个电子数据库，显示1994年至2013年间公开发表的15项大规模研究，研究直接对7～18岁哮喘患者/父母和社区/健康对照人群之间的生活质量进行比较。采用逆变量随机效应方法评估纳入人群95％可信区间（CI）的合并均数差（MD）。
   结果：与对照相比（N = 13266），小儿哮喘患者（n = 1797）的总体生活质量（MD = -7.48，CI：-10.67 / -4.29），身体机能（MD = -9.36，CI：-11.85 / -6.86），心理功能（MD = -5.00，CI：-7.17 / -2.82）和社会功能（MD = -3.76，CI：-5.80 / -1.72）更低。对于父母而言（666例病例和7328例对照），哮喘与更低的生理功能相关（MD = -10.15，CI：-12.21 / -8.08）。各研究之间的异质性通过告知类型和对照组的选择来说明。
   结论：确定生活质量受损的程度和最影响小儿哮喘患者/父母的生活质量的原因将有助于实现医疗机构多学科干预和成本-效益评估的远大目标。

 

（苏欣 审校）
Expert Rev Pharmacoecon Outcomes Res. 2015 Feb 5:1-21. [Epub ahead of print]


 

Quality of life in pediatric asthma patients and their parents: a meta-analysis on 20 years of research.
 

Silva N1, Carona C, Crespo C, Canavarro MC.

ABSTRACT
Introduction: This meta-analytic review was conducted to estimate the magnitude of quality of life (QoL) impairments in children/adolescents with asthma and their parents. Method: A systematic search in four electronic databases revealed 15 quantitative studies published between 1994-2013 that directly compared the QoL of 7- to 18-year-old asthma patients/parents to community/healthy controls. Pooled mean differences (MD) with 95% CI were estimated using the inverse-variance random-effects method. Results: Pediatric asthma patients (n = 1797) presented lower overall QoL (MD = -7.48, CI: -10.67/-4.29), physical functioning (MD = -9.36, CI: -11.85/-6.86), psychological functioning (MD = -5.00, CI: -7.17/-2.82) and social functioning (MD = -3.76, CI: -5.80/-1.72), compared to controls (n = 13,266). For parents (666 cases and 7328 controls), asthma was associated with lower physical functioning (MD = -10.15, CI: -12.21/-8.08). Between-studies heterogeneity was explained by type of informant and selection of controls. Conclusion: The ascertainment of the magnitude of QoL impairments and the most affected QoL dimensions for pediatric asthma patients/parents may contribute to the outlining of realistic goals for multidisciplinary interventions in healthcare settings and evaluate its cost-effectiveness.

Expert Rev Pharmacoecon Outcomes Res. 2015 Feb 5:1-21. [Epub ahead of print]