哮喘联盟

   摘要
   目的：研究旨在检查丹麦大型社区青少年和成人身体质量指数（BMI）和哮喘严重程度不同指标之间的关系。
   方法：纳入1,186例14～44岁受试者，对完成筛选问卷，并报告提示哮喘和/或过敏的呼吸道症状，或曾因上述症状服用过相关药物的人群进行临床检查。询问所有参与者的呼吸道症状，并测定身高和体重、皮试反应、肺功能及气道反应性。
   结果：共有516例参与者患有哮喘。平均BMI为24.9kg/m2（SD=5.1）。评估哮喘严重程度的GINA评分随着BMI增加而增加（P = 0.009）。调整年龄、性别、治疗哮喘用药和吸烟等变量后，结果仍显示有显著差异（P = 0.010）。个体哮喘症状的严重程度、咳嗽（P=0.002）、胸闷（P = 0.023）也与BMI显著相关，而与喘息和呼吸困难的严重程度无关。气道阻塞在体重指数增加的受试者身上更加显著（P <0.001），但调整协变量（p值=0.233）后，该影响消失。肺功能、气道反应、过敏体质与BMI无显著相关，但与选择治疗哮喘的药物和患者的依从性有关。
   结论：成年人体重指数的增加能预测哮喘症状的严重程度，但不是哮喘的客观特征。

 

  （杨冬 审校）
J Asthma. 2015 Jan 13:1-22. [Epub ahead of print]


 

Increased body mass index predicts severity of asthma symptoms but not objective asthma traits in a large sample of asthmatics.
 

Bildstrup L1, Backer V, Thomsen SF.
 

Abstract
AIM: To examine the relationship between body mass index (BMI) and different indicators of asthma severity in a large community-based sample of Danish adolescents and adults.
METHODS: A total of 1,186 subjects, 14-44 years of age, who in a screening questionnaire had reported a history of airway symptoms suggestive of asthma and/or allergy, or who were taking any medication for these conditions were clinically examined. All participants were interviewed about respiratory symptoms and furthermore height and weight, skin test reactivity, lung function, and airway responsiveness were measured.
RESULTS: A total of 516 individuals had asthma. The mean BMI was 24.9 kg/m2 (SD=5.1). Asthma severity measured by GINA score increased with increasing BMI (p=0.009). The result remained significant after adjusting for age, sex, medication use for asthma and smoking (p=0.010). Severity of individual asthma symptoms; cough (p=0.002) and chest tightness (p=0.023) was also significantly related to BMI, whereas severity of wheezing and shortness of breath was not. Airway obstruction was more pronounced in subjects with increased BMI (p<0.001) but the effect disappeared after adjustment for covariates (p=0.233). Lung function, airway responsiveness, and atopy were not significantly related to BMI as were use of medication for asthma and adherence to treatment.
CONCLUSIONS: In adults, increased body mass index predicts severity of asthma symptoms but not objective asthma traits.
 

J Asthma. 2015 Jan 13:1-22. [Epub ahead of print]